ArticleEpilepsia2024
Commentary on stimulus-induced arousal with transient electroencephalographic improvement distinguishes nonictal from ictal generalized periodic discharges.
Marcus C Ng, Sahar Zafar, Brandon Foreman, Jennifer Kim, Aaron F Struck, M Brandon Westover
Abstract read
In one paragraphArticle in Epilepsia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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1 · What the graph read from itWhat it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
6 authors.
Marcus C NgSection of Neurology, University of Manitoba, Winnipeg, Manitoba, Canada.
Brandon ForemanNeurology Department, University of Cincinnati, Cincinnati, Ohio, USA.
Jennifer KimSchool of Medicine, Yale University, New Haven, Connecticut, USA.
Aaron F StruckUniversity of Wisconsin-Madison, Madison, Wisconsin, USA.
Funding
Late-onset Unexplained Epilepsy as a Risk Factor for DementiaR01NS130119 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Alice D Lam · 2023 to 2026
$8.7MData-Driven Sleep Biomarkers of Brain Health, Heart Health, and MortalityR01HL161253 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CLIFFORD, GARI DAVID, MIGNOT, EMMANUEL J · 2022 to 2025
$8.3MComparative Safety of Seizure Prophylaxis within the Medicare ProgramR01AG073410 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Lidia Maria Veras Rocha de Moura · 2021 to 2026
$4.1MLow Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and InattentionR01AG073598 · NIA · STANFORD UNIVERSITY · PI Miles Berger · 2022 to 2026
$3.8MIntegrative Motor Activity Biomarker for the Risk of Alzheimer's RiskRF1AG064312 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, KUN · 2019 to 2019
$3.6MProspective Validation of Neurophysiologic Outcome Prediction in Acute Brain InjuryR01NS126282 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Aaron F Struck, Michael Brandon Westover · 2023 to 2026
$2.9MBig Data and Deep Learning for the Interictal-Ictal-Injury ContiuumR01NS107291 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WESTOVER, MICHAEL BRANDON · 2018 to 2022
$2.8MEstablishing a Brain Health Index from the Sleep ElectroencephalogramRF1NS120947 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S, THOMAS, ROBERT JOSEPH · 2021 to 2021
$2.4MComparative Effectiveness of EEG-Guided Anti-Seizure Treatment in Acute Brain InjuryR01NS131347 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Sahar F Zafar · 2024 to 2026
$1.9MEstablishing a Brain Health IndexR01NS120947 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CASH, SYDNEY S, THOMAS, ROBERT JOSEPH · 2024 to 2025
$1.6MNHLBI NIH HHS R01 HL161253NIA NIH HHS R01 AG073410NIA NIH HHS R01 AG073598NIA NIH HHS RF1 AG064312NIH HHS R01NS126282NINDS NIH HHS R01 NS107291NINDS NIH HHS R01 NS120947NINDS NIH HHS R01 NS126282NINDS NIH HHS R01 NS130119NINDS NIH HHS R01 NS131347NINDS NIH HHS RF1 NS120947
6 · The paper itselfAbstract
Here we critique recent arguments proposing to distinguish ictal from non-ictal generalized periodic discharges (GPDs) based on etiology and stimulation response, arguing that these are unreliable. We advocate for an empirical approach to GPDs: describe objectively, interpret through medication trials, and base further treatment on response. We call for evidence-based approaches considering meaningful clinical outcomes.
Indexed as
ArousalElectroencephalographyEpilepsy, GeneralizedHumansSeizuresencephalopathyGPDNCSE
Identifiers
PMID39422357
PMCPMC11649443
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