Evidence map›Paper›PMID 39422357›Full record

ArticleEpilepsia2024

Commentary on stimulus-induced arousal with transient electroencephalographic improvement distinguishes nonictal from ictal generalized periodic discharges.

Marcus C Ng, Sahar Zafar, Brandon Foreman, Jennifer Kim, Aaron F Struck, M Brandon Westover

Abstract read
In one paragraph

Article in Epilepsia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marcus C NgSection of Neurology, University of Manitoba, Winnipeg, Manitoba, Canada.
Sahar ZafarMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-5252-5376
Brandon ForemanNeurology Department, University of Cincinnati, Cincinnati, Ohio, USA.
Jennifer KimSchool of Medicine, Yale University, New Haven, Connecticut, USA.
Aaron F StruckUniversity of Wisconsin-Madison, Madison, Wisconsin, USA.
M Brandon WestoverBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-4803-312X

Funding

Late-onset Unexplained Epilepsy as a Risk Factor for DementiaR01NS130119 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Alice D Lam · 2023 to 2026
$8.7M
Data-Driven Sleep Biomarkers of Brain Health, Heart Health, and MortalityR01HL161253 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CLIFFORD, GARI DAVID, MIGNOT, EMMANUEL J · 2022 to 2025
$8.3M
Comparative Safety of Seizure Prophylaxis within the Medicare ProgramR01AG073410 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Lidia Maria Veras Rocha de Moura · 2021 to 2026
$4.1M
Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and InattentionR01AG073598 · NIA · STANFORD UNIVERSITY · PI Miles Berger · 2022 to 2026
$3.8M
Integrative Motor Activity Biomarker for the Risk of Alzheimer's RiskRF1AG064312 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, KUN · 2019 to 2019
$3.6M
Prospective Validation of Neurophysiologic Outcome Prediction in Acute Brain InjuryR01NS126282 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Aaron F Struck, Michael Brandon Westover · 2023 to 2026
$2.9M
Big Data and Deep Learning for the Interictal-Ictal-Injury ContiuumR01NS107291 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WESTOVER, MICHAEL BRANDON · 2018 to 2022
$2.8M
Establishing a Brain Health Index from the Sleep ElectroencephalogramRF1NS120947 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S, THOMAS, ROBERT JOSEPH · 2021 to 2021
$2.4M
Comparative Effectiveness of EEG-Guided Anti-Seizure Treatment in Acute Brain InjuryR01NS131347 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Sahar F Zafar · 2024 to 2026
$1.9M
Establishing a Brain Health IndexR01NS120947 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CASH, SYDNEY S, THOMAS, ROBERT JOSEPH · 2024 to 2025
$1.6M
NHLBI NIH HHS R01 HL161253NIA NIH HHS R01 AG073410NIA NIH HHS R01 AG073598NIA NIH HHS RF1 AG064312NIH HHS R01NS126282NINDS NIH HHS R01 NS107291NINDS NIH HHS R01 NS120947NINDS NIH HHS R01 NS126282NINDS NIH HHS R01 NS130119NINDS NIH HHS R01 NS131347NINDS NIH HHS RF1 NS120947
6 · The paper itself

Abstract

Here we critique recent arguments proposing to distinguish ictal from non-ictal generalized periodic discharges (GPDs) based on etiology and stimulation response, arguing that these are unreliable. We advocate for an empirical approach to GPDs: describe objectively, interpret through medication trials, and base further treatment on response. We call for evidence-based approaches considering meaningful clinical outcomes.

Indexed as

ArousalElectroencephalographyEpilepsy, GeneralizedHumansSeizuresencephalopathyGPDNCSE

Identifiers

PMID39422357
PMCPMC11649443

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.