Evidence map›Paper›PMID 39421989›Full record

ReviewReviews on recent clinical trials2025

Ongoing Clinical Trials for Polycystic Ovarian Syndrome (PCOS) Afflicted Infertility in Women: A Narrative Review.

Ratnakar Shukla, Muskan Chadha, Anisha Adya, Aastha Yadav, Nidhi Singh, Ranjeet Singh Chauhan, Afza Ahmad, Rohit Kumar Tiwari

Abstract readReview
PubMed Publisher
In one paragraph

Review in Reviews on recent clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ratnakar ShuklaDepartment of Clinical Research, Sharda School of Allied Health Sciences, Sharda University Greater Noida, 201310, India.
Muskan ChadhaDepartment of Nutrition and Dietetics, Sharda School of Allied Health Sciences, Sharda University, Greater Noida, 201310, India.
Anisha AdyaDepartment of Nutrition and Dietetics, Sharda School of Allied Health Sciences, Sharda University, Greater Noida, 201310, India.
Aastha YadavDepartment of Clinical Research, Sharda School of Allied Health Sciences, Sharda University Greater Noida, 201310, India.
Nidhi SinghDepartment of Clinical Research, Sharda School of Allied Health Sciences, Sharda University Greater Noida, 201310, India.
Ranjeet Singh ChauhanDepartment of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh-226014, India.
Afza AhmadDepartment of Public Health, Dr. Giri Lal Gupta Institute of Public Health and Public Affairs, University of Lucknow, Lucknow, Uttar Pradesh, 226007, India.
Rohit Kumar TiwariDepartment of Clinical Research, Sharda School of Allied Health Sciences, Sharda University Greater Noida, 201310, India.ORCID 0000-0001-8215-633X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycystic Ovary Syndrome (PCOS) is a highly prevalent endocrine disorder that affects women of reproductive age. PCOS is further correlated with infertility, menstrual dysfunction, and hyperandrogenism. Despite the advanced understanding of reproductive biology, the exact causes of PCOS remain ambiguous. Nevertheless, several factors are believed to contribute to the development of PCOS, including insulin resistance, hyperinsulinemia, obesity, and genetic predispositions. The diagnosis of PCOS is complicated by its phenotypic heterogeneity, which manifests differently in different individuals. Presently, the therapeutic management of PCOS-afflicted infertility depends upon proper pharmaceutical-based therapies aimed at treating underlying symptoms, such as the use of clomiphene citrate, metformin, ovulation-inducing agents, anti-androgens, exogenous gonadotropin administration, laparoscopic ovarian drilling, and in vitro fertilization. The present review focuses on narrating present therapeutic interventions along with lifestyle modifications in PCOS. Furthermore, it focuses on the ongoing clinical trials of various chemotherapeutics to counter PCOS-induced infertility among women.

Indexed as

Infertility, FemalePolycystic Ovary SyndromeClinical Trials as TopicClomipheneFemaleFertility Agents, FemaleHumansClomipheneFertility Agents, Femaleendocrine disorderinfertilityinsulin resistancemetformin.PCOStherapeutics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.