Evidence map›Paper›PMID 39421951›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2024

Sweden surpasses the UNAIDS 95-95-95 target: estimating HIV-1 incidence, 2003 to 2022.

Erik Lundgren, Macauley Locke, Ethan Romero-Severson, Mira Dimitrijevic, Maria Axelsson, Emmi Andersson, Christina Carlander, Johanna Brännström, Hans Norrgren, Fredrik Mansson and 6 more

Abstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Observational
  5. Late HIV diagnosis: trends, risk factors, and progress toward the 2025 target of <20% late diagnosis in 23 EU/EEA countries, 2022 to 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  6. Article
  7. Progress towards HIV transmission elimination targets: model-based estimation of incidence and the extent of undiagnosed infection, Scotland, 1981 to 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Erik LundgrenThese authors contributed equally to this work and share first authorship.
Macauley LockeThese authors contributed equally to this work and share first authorship.
Ethan Romero-SeversonTheoretical Biology & Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, United States.
Mira DimitrijevicTheoretical Biology & Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, United States.
Maria AxelssonPublic Health Agency of Sweden, Solna, Sweden.
Emmi AnderssonDepartment of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Christina CarlanderDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Johanna BrännströmDepartment of Clinical Science and Education (KISÖS), Karolinska Institutet, Stockholm, Sweden.
Hans NorrgrenDepartment of Clinical Sciences Lund, Division of Infection Medicine, Lund University, Lund, Sweden.
Fredrik ManssonDepartment of Translational Medicine, Clinical Infection Medicine, Lund University, Malmö, Sweden.
Olof ElvstamDepartment of Infectious Diseases, Växjö Central Hospital, Växjö, Sweden.
Magnus GisslénRegion Västra Götaland, Department of Infectious Diseases, Sahlgrenska University Hospital, Gothenburg, Sweden.
Lisa FohlinRegion Jämtland Härjedalen, Östersund, Sweden.
Anders SönnerborgDepartment of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Jan AlbertDepartment of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.
Thomas LeitnerTheoretical Biology & Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, United States.

Funding

Reconstructing HIV Epidemics from HIV PhylogeneticsR01AI087520 · NIAID · TRIAD NATIONAL SECURITY, LLC · PI Thomas K. Leitner · 2010 to 2026
$11.2M
Leveraging public health genotyping databases for near real-time HIV surveillanceR01AI135946 · NIAID · TRIAD NATIONAL SECURITY, LLC · PI LEITNER, THOMAS K. · 2019 to 2023
$4.2M
Next-generation algorithms using multiple biomarkers for precise estimation of HIV infection duration and population level incidenceR01AI152897 · NIAID · TRIAD NATIONAL SECURITY, LLC · PI LEITNER, THOMAS K. · 2021 to 2025
$3.5M
NIAID NIH HHS R01 AI087520NIAID NIH HHS R01 AI135946NIAID NIH HHS R01 AI152897
6 · The paper itself

Abstract

BackgroundSweden reached the UNAIDS 90-90-90 target in 2015. It is important to reassess the HIV epidemiological situation due to ever-changing migration patterns, the roll-out of PrEP and the impact of the COVID-19 pandemic.AimWe aimed to assess the progress towards the UNAIDS 95-95-95 targets in Sweden by estimating the proportion of undiagnosed people with HIV (PWHIV) and HIV incidence trends.MethodsWe used routine laboratory data to inform a biomarker model of time since infection. When available, we used previous negative test dates, arrival dates for PWHIV from abroad and transmission modes to inform our incidence model. We also used data collected from the Swedish InfCareHIV register on antiretroviral therapy (ART).ResultsThe yearly incidence of HIV in Sweden decreased after 2014. In part, this was because the fraction of undiagnosed PWHIV had decreased almost twofold since 2006. After 2015, three of four PWHIV in Sweden were diagnosed within 1.9 and 3.2 years after infection among men who have sex with men and in heterosexual groups, respectively. While 80% of new PWHIV in Sweden acquired HIV before immigration, they make up 50% of the current PWHIV in Sweden. By 2022, 96% of all PWHIV in Sweden had been diagnosed, and 99% of them were on ART, with 98% virally suppressed.ConclusionsBy 2022, about half of all PWHIV in Sweden acquired HIV abroad. Using our new biomarker model, we assess that Sweden has reached the UNAIDS goal at 96-99-98.

Indexed as

COVID-19HIV-1HIV InfectionsAdultAnti-HIV AgentsFemaleHomosexuality, MaleHumansIncidenceMaleMiddle AgedPandemicsRegistriesSARS-CoV-2SwedenYoung AdultAnti-HIV AgentsbiomarkersHIVincidencemodellingUNAIDS

Identifiers

PMID39421951
PMCPMC11487918

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.