Evidence map›Paper›PMID 39421789›Full record

ArticleBiomedical optics express2024

OCTA-ReVA: an open-source toolbox for comprehensive retinal vessel feature analysis in optical coherence tomography angiography.

Albert K Dadzie, David Le, Mansour Abtahi, Behrouz Ebrahimi, Tobiloba Adejumo, Taeyoon Son, Michael J Heiferman, Jennifer I Lim, Xincheng Yao

Abstract read
In one paragraph

Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. OCTA-ReVABiomedical optics express · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Albert K DadzieDepartment of Biomedical Engineering, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID https://orcid.org/0000-0002-3466-5188
David LeDepartment of Biomedical Engineering, University of Illinois Chicago, Chicago, IL 60607, USA.
Mansour AbtahiDepartment of Biomedical Engineering, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID https://orcid.org/0000-0001-7463-9470
Behrouz EbrahimiDepartment of Biomedical Engineering, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID https://orcid.org/0000-0003-3390-7330
Tobiloba AdejumoDepartment of Biomedical Engineering, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID https://orcid.org/0000-0001-8500-2168
Taeyoon SonDepartment of Biomedical Engineering, University of Illinois Chicago, Chicago, IL 60607, USA.
Michael J HeifermanDepartment of Ophthalmology and Visual Sciences, University of Illinois Chicago, Chicago, IL 60612, USA.
Jennifer I LimDepartment of Ophthalmology and Visual Sciences, University of Illinois Chicago, Chicago, IL 60612, USA.
Xincheng YaoDepartment of Biomedical Engineering, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID https://orcid.org/0000-0002-0356-3242

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SHUKLA, DEEPAK · 1985 to 2025
$14.8M
Functional imaging of retinal photoreceptorsR01EY023522 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI YAO, XINCHENG · 2014 to 2024
$3.5M
Nonmydriatic ultra-widefield fundus photography employing trans-pars-planar illuminationR01EY029673 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHAN, ROBISON VERNON PAUL, YAO, XINCHENG · 2019 to 2022
$1.8M
Differential artery-vein analysis in OCT angiography for objective classification of diabetic retinopathyR01EY030842 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LIM, JENNIFER IRENE, YAO, XINCHENG · 2020 to 2023
$1.7M
Functional tomography of neurovascular coupling interactions in healthy and diseased retinasR01EY030101 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI YAO, XINCHENG · 2019 to 2022
$1.4M
NEI NIH HHS P30 EY001792NEI NIH HHS R01 EY023522NEI NIH HHS R01 EY029673NEI NIH HHS R01 EY030101NEI NIH HHS R01 EY030842
6 · The paper itself

Abstract

Optical coherence tomography angiography (OCTA) has significantly advanced the study and diagnosis of eye diseases. However, current clinical OCTA systems and software tools lack comprehensive quantitative analysis capabilities, limiting their full clinical utility. This paper introduces the OCTA Retinal Vessel Analyzer (OCTA-ReVA), a versatile open-source platform featuring a user-friendly graphical interface designed for the automated extraction and quantitative analysis of OCTA features. OCTA-ReVA includes traditional established OCTA features based on binary vascular image processing, such as blood vessel density (BVD), foveal avascular zone area (FAZ-A), blood vessel tortuosity (BVT), and blood vessel caliber (BVC). Additionally, it introduces new features based on blood perfusion intensity processing, such as perfusion intensity density (PID), vessel area flux (VAF), and normalized blood flow index (NBFI), which provide deeper insights into retinal perfusion conditions. These additional capabilities are crucial for the early detection and monitoring of retinal diseases. OCTA-ReVA demystifies the intricate task of retinal vasculature quantification, offering a robust tool for researchers and clinicians to objectively evaluate eye diseases and enhance the precision of retinal health assessments.

Identifiers

PMID39421789
PMCPMC11482184

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.