Evidence map›Paper›PMID 39421783›Full record

ArticleBiomedical optics express2024

Prediction of the response to antiangiogenic sunitinib therapy by non-invasive hybrid diffuse optics in renal cell carcinoma.

Miguel Mireles, Gabriela Jiménez-Valerio, Jordi Morales-Dalmau, Johannes D Johansson, Mar Martínez-Lozano, Ernesto E Vidal-Rosas, Valentí Navarro-Pérez, David R Busch, Oriol Casanovas, Turgut Durduran and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Miguel MirelesICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Barcelona, Spain.ORCID https://orcid.org/0000-0002-6579-3844
Gabriela Jiménez-ValerioComputational Optics and Translational Imaging Lab, Northeastern University, Boston, Massachusetts 02115, USA.
Jordi Morales-DalmauICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Barcelona, Spain.
Johannes D JohanssonICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Barcelona, Spain.ORCID https://orcid.org/0000-0003-4910-0291
Mar Martínez-LozanoTumor Angiogenesis Group, ProCURE, Catalan Institute of Oncology - IDIBELL, 08908 L'Hospitalet de Llobregat, Spain.
Ernesto E Vidal-RosasICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Barcelona, Spain.ORCID https://orcid.org/0000-0002-4486-7592
Valentí Navarro-PérezClinical Research Unit, Institut Català d'Oncologia, 08908 L'Hospitalet de Llobregat, Spain.
David R BuschUniversity of Texas Southwestern Medical Center, Departments of Anesthesiology and Pain Management, Neurology, and Biomedical Engineering Dallas, Texas 75390-9003, USA.ORCID https://orcid.org/0000-0002-9488-944X
Oriol CasanovasTumor Angiogenesis Group, ProCURE, Catalan Institute of Oncology - IDIBELL, 08908 L'Hospitalet de Llobregat, Spain.
Turgut DurduranICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Barcelona, Spain.ORCID https://orcid.org/0000-0001-5838-1027
Clara VilchesICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Barcelona, Spain.ORCID https://orcid.org/0000-0002-2695-2128

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, broadband diffuse reflectance spectroscopy (DRS) and diffuse correlation spectroscopy (DCS) were used to quantify deep tissue hemodynamics in a patient-derived orthotopic xenograft mouse model of clear cell renal cancer undergoing antiangiogenic treatment. A cohort of twenty-two mice were treated with sunitinib and compared to thirteen control untreated mice, and monitored by DRS/DCS. A reduction in total hemoglobin concentration (THC, p = 0.03), oxygen saturation (SO

Identifiers

PMID39421783
PMCPMC11482189

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.