Evidence map›Paper›PMID 39421776›Full record

ArticleBiomedical optics express2024

Microscope integrated MHz optical coherence tomography system for neurosurgery: development and clinical in-vivo imaging.

Wolfgang Draxinger, Nicolas Detrez, Paul Strenge, Veit Danicke, Dirk Theisen-Kunde, Lion Schützeck, Sonja Spahr-Hess, Patrick Kuppler, Jessica Kren, Wolfgang Wieser and 3 more

Abstract read
In one paragraph

Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Label-free viability assessment ofBiomedical optics express · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wolfgang DraxingerUniversität zu Lübeck, Institut für Biomedizinische Optik (BMO), Peter-Monnik-Weg 4, 23562 Lübeck, Germany.ORCID https://orcid.org/0000-0002-9413-3474
Nicolas DetrezMedizinisches Laserzentrum Lübeck GmbH (MLL), Peter-Monnik-Weg 4, 23562 Lübeck, Germany.ORCID https://orcid.org/0009-0005-7864-9429
Paul StrengeMedizinisches Laserzentrum Lübeck GmbH (MLL), Peter-Monnik-Weg 4, 23562 Lübeck, Germany.
Veit DanickeMedizinisches Laserzentrum Lübeck GmbH (MLL), Peter-Monnik-Weg 4, 23562 Lübeck, Germany.
Dirk Theisen-KundeMedizinisches Laserzentrum Lübeck GmbH (MLL), Peter-Monnik-Weg 4, 23562 Lübeck, Germany.
Lion SchützeckMedizinisches Laserzentrum Lübeck GmbH (MLL), Peter-Monnik-Weg 4, 23562 Lübeck, Germany.
Sonja Spahr-HessUniversitätsklinikum Schleswig-Holstein (UKSH), Ratzeburger Allee 160, 23538 Lübeck, Germany.
Patrick KupplerUniversitätsklinikum Schleswig-Holstein (UKSH), Ratzeburger Allee 160, 23538 Lübeck, Germany.
Jessica KrenUniversitätsklinikum Schleswig-Holstein (UKSH), Ratzeburger Allee 160, 23538 Lübeck, Germany.
Wolfgang WieserOptores GmbH, Gollierstr. 70, 80339 Munich, Germany.
Matteo Mario BonsantoUniversitätsklinikum Schleswig-Holstein (UKSH), Ratzeburger Allee 160, 23538 Lübeck, Germany.
Ralf BrinkmannUniversität zu Lübeck, Institut für Biomedizinische Optik (BMO), Peter-Monnik-Weg 4, 23562 Lübeck, Germany.
Robert HuberUniversität zu Lübeck, Institut für Biomedizinische Optik (BMO), Peter-Monnik-Weg 4, 23562 Lübeck, Germany.ORCID https://orcid.org/0000-0001-9785-6574

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurosurgical interventions on the brain are impeded by the requirement to keep damages to healthy tissue at a minimum. A new contrast channel enhancing the visual separation of malign tissue should be created. A commercially available surgical microscope was modified with adaptation optics adapting the MHz speed optical coherence tomography (OCT) imaging system developed in our group. This required the design of a scanner optics and beam delivery system overcoming constraints posed by the mechanical and optical parameters of the microscope. High quality volumetric OCT C-scans with dense sample spacing can be acquired in-vivo as part of surgical procedures within seconds and are immediately available for post-processing.

Identifiers

PMID39421776
PMCPMC11482179

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.