ArticleBiomedical optics express2024
Investigating the effect of limited spectral information on NIRS-derived changes in hemoglobin and cytochrome-c-oxidase concentration with a diffusion-based model.
Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- MW-FlexNIRS: wearable, low-cost, LED-based, multi-wavelength NIRS oximeter for cytochrome c oxidase recovery in neonates.Biomedical optics express · 2026Article
- Digital instrument simulator to optimize the development of hyperspectral systems: application for intraoperative functional brain mapping.Journal of biomedical optics · 2025Article
- Article
- Diffuse Optical Spectroscopy: Technology and Applications: introduction to the feature issue.Biomedical optics express · 2024Article
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Authors and funding
5 authors.
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Abstract
This paper investigates the theoretical capability of near-infrared spectroscopy (NIRS) systems to accurately measure changes in the oxidation state of cerebral cytochrome-c-oxidase (CCO) alongside the hemoglobins, for a deeper understanding of NIRS limitations. Concentration changes of oxy and deoxyhemoglobin (HbO and HbR) indicate the oxygen status of blood vessels and correlate with several other physiological parameters across different pathologies. The oxidation state of CCO indicates cellular energy usage efficiency through oxidative metabolism, potentially serving as a biomarker for brain and other tissue disorders. This study employs an analytical model based on the diffusion equation and statistical analyses to explore the dependency of estimated concentration changes on various systematic parameters, such as choice of wavelengths, spectral bandwidth, and uncertainties in extinction coefficient (
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