Evidence map›Paper›PMID 39421764›Full record

ArticleBiomedical optics express2024

Age dependence of the average refractive index of the isolated human crystalline lens.

Ramya Natarajan, Bianca Maceo Heilman, Marco Ruggeri, Arthur Ho, Vivek M Singh, Robert Augusteyn, Jean-Marie Parel, Pravin K Vaddavalli, Fabrice Manns

Abstract read
In one paragraph

Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ramya NatarajanOphthalmic Biophysics Laboratory, L V Prasad Eye Institute, Hyderabad, Telangana, India.ORCID https://orcid.org/0000-0002-5651-3206
Bianca Maceo HeilmanOphthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Marco RuggeriOphthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID https://orcid.org/0000-0001-6491-8476
Arthur HoOphthalmic Biophysics Laboratory, L V Prasad Eye Institute, Hyderabad, Telangana, India.ORCID https://orcid.org/0000-0002-7156-7800
Vivek M SinghOphthalmic Biophysics Laboratory, L V Prasad Eye Institute, Hyderabad, Telangana, India.
Robert AugusteynSchool of Optometry and Vision Science, The University of New South Wales, Sydney, NSW, Australia.
Jean-Marie ParelOphthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Pravin K VaddavalliOphthalmic Biophysics Laboratory, L V Prasad Eye Institute, Hyderabad, Telangana, India.
Fabrice MannsOphthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We measured the average group refractive index (RI) of 120 isolated lenses from 120 human donors (age: 0.03 to 61 years). The average group RI was calculated from a measurement of the optical thickness of the lens using optical coherence tomography and the apparent window shift of the test chamber caused by the lens. The estimated measurement uncertainty was ±0.004. The group RI at 880 nm was converted to phase RI at 589 nm using the dispersion equation of water and protein. From 2 to 61 years, the mean value of the RI was 1.415 ± 0.002 (group index at 880 nm) and 1.406 ± 0.002 (phase index at 589 nm) independent of age (p = 0.774). Two lenses from donors of age 0.33 and 3 months had significantly lower RI (group index: 1.405 and 1.403; phase index: 1.396 and 1.394). From age 2 to 61, the average lens RI is constant with age within the measurement uncertainty (±0.004).

Identifiers

PMID39421764
PMCPMC11482174

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.