Evidence map›Paper›PMID 39421760›Full record

ArticleBiomedical optics express2024

Photodynamic opening of the blood-brain barrier affects meningeal lymphatics and the brain's drainage in healthy male mice.

Inna Blokhina, Andrey Terskov, Arina Evsiukova, Alexander Dubrovsky, Viktoria Adushkina, Daria Zlatogorskaya, Alexander Dmitrenko, Matvey Tuzhilkin, Maria Manzhaeva, Valeria Krupnova and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Inna BlokhinaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.ORCID https://orcid.org/0000-0003-1517-0857
Andrey TerskovDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Arina EvsiukovaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Alexander DubrovskyInstitute of Physics, Saratov State University Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Viktoria AdushkinaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Daria ZlatogorskayaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Alexander DmitrenkoDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Matvey TuzhilkinDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Maria ManzhaevaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Valeria KrupnovaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Egor IlyukovInstitute of Physics, Saratov State University Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Dmitry MyagkovInstitute of Physics, Saratov State University Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Dmitry TuktarovInstitute of Physics, Saratov State University Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Sergey PopovInstitute of Physics, Saratov State University Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Maria TzoyInstitute of Physics, Saratov State University Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Alexander ShirokovDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.ORCID https://orcid.org/0000-0003-4321-735X
Ivan FedosovInstitute of Physics, Saratov State University Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Oxana Semyachkina-GlushkovskayaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we present the new vascular effects of photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA). PDT with 5-ALA induces a leakage of both the meningeal and cerebral blood vessels. The extravasation of photo-excited 5-ALA from the leaky blood vessels into the meninges causes photo-damage of the meningeal lymphatics (MLVs) leading to a dramatic reducing the MLV network and brain's drainage. The PDT-induced impairment of lymphatic regulation of brain's drainage can lead to excessive accumulation of fluids in brain tissues, which is important to consider in the PDT therapy for brain diseases as s possible side effect of PDT with 5-ALA.

Identifiers

PMID39421760
PMCPMC11482160

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.