ArticleCHEST pulmonary2024
The Upper Limit of Normal Rate of Lung Function Decline in Healthy Adults in the Framingham Heart Study.
Article in CHEST pulmonary, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Respiratory injuries among California career firefighters, 2000-2019.Annals of the American Thoracic Society · 2026Article
- Patient specific characteristics and risk of iatrogenic pneumothorax after CT-guided biopsy of the lung parenchyma.European clinical respiratory journal · 2026Article
- Integrated Care for COPD in the Elderly: Impact on Healthcare Utilization Across Healthcare Settings.International journal of chronic obstructive pulmonary disease · 2026Article
- Pulmonary Function Changes in Fighter Pilots with Positive Pressure Ventilation.Healthcare (Basel, Switzerland) · 2025Article
- Sex Differences in Chronic Obstructive Pulmonary Disease: Implications for Pathogenesis, Diagnosis, and Treatment.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundLung function declines over the course of adulthood; however, a consensus on the normal range of decline in an individual's lung function is lacking. RESEARCH QUESTION: What is the normal range and the upper limit of normal (ULN) decline in lung function in adults without prior tobacco use, occupational dust exposure, or a known diagnosis or symptoms of cardiopulmonary disease? STUDY DESIGN AND
methodsA retrospective analysis of healthy individuals who have never smoked (N = 1,305) from the Framingham Heart Study with repeated lung function meeting standards for acceptability and reproducibility was conducted. Longitudinal change was derived using a linear mixed effects model and estimated to a 6-year interval. The ULN decline was defined as the 95th percentile.
resultsThe mean follow-up between spirometry examinations was 5.5 years, whereas the mean follow-up between diffusing capacity for carbon monoxide studies was 5.9 years. Decline in FEV
interpretationLung function decline is nonlinear and accelerates with age. In this cohort, the ULN decline over 6 years often exceeded current guidelines for interpreting significant longitudinal change in lung function.
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Registered trials
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