Evidence map›Paper›PMID 39421704›Full record

ArticleContemporary oncology (Poznan, Poland)2024

Evaluation of outcome and safety profile in high-dose BEAM and Benda-EAM chemotherapy with subsequent autologous stem cell transplantation in lymphoma patients.

Kinga Krawiec, Piotr Strzałka, Olga Racińska, Marcin Kędzior, Hubert Sowul, Wojciech Salamon, Kacper Kościelny, Michał Kośny, Damian Mikulski, Agnieszka Pluta and 1 more

Abstract read
In one paragraph

Article in Contemporary oncology (Poznan, Poland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kinga KrawiecDepartment of Hematology, Medical University of Łódź, Łódź, Poland.
Piotr StrzałkaDepartment of Hematology, Medical University of Łódź, Łódź, Poland.
Olga RacińskaMedical University of Łódź, Łódź, Poland.
Marcin KędziorMedical University of Łódź, Łódź, Poland.
Hubert SowulMedical University of Łódź, Łódź, Poland.
Wojciech SalamonMedical University of Łódź, Łódź, Poland.
Kacper KościelnyMedical University of Łódź, Łódź, Poland.
Michał KośnyDepartment of Hematology, Medical University of Łódź, Łódź, Poland.
Damian MikulskiDepartment of Biostatistics and Translational Medicine, Medical University of Łódź, Łódź, Poland.
Agnieszka PlutaDepartment of Hematology, Medical University of Łódź, Łódź, Poland.
Agnieszka WierzbowskaDepartment of Hematology, Medical University of Łódź, Łódź, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Autologous hematopoietic stem cell transplantation (auto- HSCT) preceded by high-dose chemotherapy is a mainstay in relapsed/refractory lymphoma. The study aimed to compare the efficacy and adverse event profile between BEAM and Benda-EAM (BeEAM) regimens and to evaluate prognostic factors for survival in lymphoma patients undergoing auto-HSCT. Material and methods: We present a single-center retrospective analysis of 82 lymphoma patients (median age 52; IQR 38.2-62.2) who received BEAM (47.6%) or BeEAM (52.4%) followed by auto-HSCT between January 2015 and December 2021. Results: During the post-HSCT period 58% of patients experienced febrile neutropenia (51.3% vs. 64.3% in BEAM and BeEAM, respectively; Conclusions: Conditioning with BEAM and BeEAM regimens is associated with comparable post-transplant outcomes. The toxicity of these regimens is comparable; however, BEAM is associated with a higher risk of pneumonia, while BeEAM is associated with a higher risk of mucositis.

Indexed as

auto- HSCTBEAMBeEAMlymphoma

Identifiers

PMID39421704
PMCPMC11480906

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.