Evidence map›Paper›PMID 39421669›Full record

SynthesisFrontiers in pharmacology2024

The efficacy of azithromycin combined with seven types of Chinese medicine injections in the treatment of

Xinggui Huang, Sian Tao, Chenhao Liu, Xiaoluo Sun, Yule Hao, Yuqi Ma, Yi Liu, Jibin Liu

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xinggui HuangSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Sian TaoSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Chenhao LiuSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Xiaoluo SunSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yule HaoSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yuqi MaSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yi LiuSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Jibin LiuSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methods: Randomized controlled trials (RCTs) evaluating azithromycin in combination with seven types of CMIs for MPP in children were identified based on inclusion criteria and assessed using the revised Cochrane risk of bias tool (RoB 2.0). R 4.3.1 and STATA 15.0 were employed to generate ranking probabilities and perform network meta-analysis. Competing interventions were ranked using the surface under the cumulative ranking (SUCRA) probabilities. Results: A comprehensive analysis was performed on 155 RCTs involving 15,014 patients and 8 therapeutic strategies within this Bayesian network meta-analysis (BNMA). The results indicated that AZ combined with seven types of CMIs was more effective than azithromycin alone in overall outcomes. Notably, azithromycin combined with Chuanhuning injection (AZ + CHN) achieved the highest ranking in improving the clinical effectiveness rate (SUCRA, 80.89%); regarding secondary outcome measures, azithromycin combined with Yanhuning injection (AZ + YHN) had the highest probability of improving four different outcomes: disappearance time of cough (SUCRA, 80.01%), disappearance time of pulmonary rale (SUCRA, 87.77%), disappearance time of fever (SUCRA, 95.70%), and disappearance time of pulmonary shadows in Conclusion: This study highlights the potential benefits of seven types of Chinese medicine injections as adjunctive therapy for Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/#recordDetails/.

Indexed as

antibiotic resistanceazithromycinBayesian network meta-analysisChinese medicine injectionsMycoplasma pneumoniae pneumonia

Identifiers

PMID39421669
PMCPMC11484089

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.