Evidence map›Paper›PMID 39421592›Full record

ArticleiScience2024

Macrophages-derived high-mobility group box-1 protein induces endothelial progenitor cells pyroptosis.

Menghao Zeng, Guibin Liang, Fangfang Yuan, Shanshan Yan, Jie Liu, Zhihui He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The role of HMGB1 in vascular endothelial cells.Apoptosis : an international journal on programmed cell death · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Menghao ZengDepartment of Critical Care Medicine, the Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Guibin LiangDepartment of Critical Care Medicine, the Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Fangfang YuanDepartment of Critical Care Medicine, the Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Shanshan YanDepartment of Critical Care Medicine, the Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Jie LiuDepartment of Critical Care Medicine, the Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Zhihui HeDepartment of Critical Care Medicine, the Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelial dysfunction is an important factor in the progress of sepsis. Endothelial progenitor cells (EPCs) are the precursor cells of endothelial cells and play a crucial role in the prognosis and treatment of sepsis. EPCs in the peripheral blood of patients with sepsis undergo pyroptosis, but the mechanism remains much of unknown. Serum high-mobility group box-1 (HMGB1) is significantly elevated in patients with sepsis, but whether it is related to EPCs pyroptosis is unknown. We used a cell model of sepsis

Indexed as

Cell biologyImmunologyPathophysiology

Identifiers

PMID39421592
PMCPMC11483297

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.