Evidence map›Paper›PMID 39421463›Full record

ArticlePlant direct2024

Context effects on repair of 5'-overhang DNA double-strand breaks induced by Cas12a in Arabidopsis.

Sébastien Lageix, Miguel Hernandez, Maria E Gallego, Jérémy Verbeke, Yannick Bidet, Sandrine Viala, Charles I White

Abstract read
In one paragraph

Article in Plant direct, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sébastien LageixInstitut de Génétique, Reproduction et Développement, UMR CNRS 6293 - INSERM U1103 - Université Clermont Auvergne, Bât. CRBC, Faculté de Médecine Clermont-Ferrand Cedex 1 France.
Miguel HernandezInstitut de Génétique, Reproduction et Développement, UMR CNRS 6293 - INSERM U1103 - Université Clermont Auvergne, Bât. CRBC, Faculté de Médecine Clermont-Ferrand Cedex 1 France.ORCID https://orcid.org/0000-0002-7633-0810
Maria E GallegoInstitut de Génétique, Reproduction et Développement, UMR CNRS 6293 - INSERM U1103 - Université Clermont Auvergne, Bât. CRBC, Faculté de Médecine Clermont-Ferrand Cedex 1 France.
Jérémy VerbekeInstitut de Génétique, Reproduction et Développement, UMR CNRS 6293 - INSERM U1103 - Université Clermont Auvergne, Bât. CRBC, Faculté de Médecine Clermont-Ferrand Cedex 1 France.
Yannick BidetLaboratoire d'Oncologie Moléculaire, U1240 Imagerie Moléculaire et Stratégies Théranostiques, Université Clermont Auvergne, Centre Jean Perrin, INSERM Clermont-Ferrand France.ORCID https://orcid.org/0000-0002-9624-8195
Sandrine VialaLaboratoire d'Oncologie Moléculaire, U1240 Imagerie Moléculaire et Stratégies Théranostiques, Université Clermont Auvergne, Centre Jean Perrin, INSERM Clermont-Ferrand France.
Charles I WhiteInstitut de Génétique, Reproduction et Développement, UMR CNRS 6293 - INSERM U1103 - Université Clermont Auvergne, Bât. CRBC, Faculté de Médecine Clermont-Ferrand Cedex 1 France.ORCID https://orcid.org/0000-0001-8152-5797

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sequence-specific endonucleases have been key to the study of the mechanisms and control of DNA double-strand break (DSB) repair and recombination, and the availability of CRISPR-Cas nucleases over the last decade has driven rapid progress in the understanding and application of targeted recombination in many organisms, including plants. We present here an analysis of recombination at targeted chromosomal 5' overhang DSB generated by the FnCas12a endonuclease in the plant,

Indexed as

ArabidopsisCas12aDNA repairDSB repairrecombination

Identifiers

PMID39421463
PMCPMC11486519

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.