Evidence map›Paper›PMID 39421400›Full record

Article... International Conference on Manipulation Automation and Robotics at Small Scales (MARSS). International Conference on Manipulation Automation and Robotics at Small Scales2023

Targeted Vibration-Induced Necrosis in Liver Cancer Cells using Paramagnetic Microrobots.

Sudipta Mallick, Max Sokolich, David Rivas, Sambeeta Das

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ... International Conference on Manipulation Automation and Robotics at Small Scales (MARSS). International Conference on Manipulation Automation and Robotics at Small Scales, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Peanut Shaped Microrobots for Anticancer Therapy.... International Conference on Manipulation Automation and Robotics at Small Scales (MARSS). International Conference on Manipulation Automation and Robotics at Small Scales · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sudipta MallickDepartment of Mechanical Engineering, University of Delaware, Newark, 19716, Delaware, USA.
Max SokolichDepartment of Mechanical Engineering, University of Delaware, Newark, 19716, Delaware, USA.
David RivasDepartment of Mechanical Engineering, University of Delaware, Newark, 19716, Delaware, USA.
Sambeeta DasDepartment of Mechanical Engineering, University of Delaware, Newark, 19716, Delaware, USA.

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI MELINDA K DUNCAN · 2012 to 2026
$67.2M
Controlling Cellular Fate using MicromachinesR35GM147451 · NIGMS · UNIVERSITY OF DELAWARE · PI Sambeeta Das · 2022 to 2026
$2.0M
NIGMS NIH HHS P20 GM103446NIGMS NIH HHS R35 GM147451
6 · The paper itself

Abstract

Therapeutic delivery of anti-cancer drugs is a major goal of modern medicine. However, developing methods to target cancer cells for more effective treatment and reduced side effects is a significant ongoing challenge. Microrobots have recently been studied for their ability to navigate difficult-to-reach regions in the human body to deliver therapeutics for microscopically localized interventions. Using microrobots for targeted and local therapy therefore, is a promising revolutionary treatment method. In this study, magnetic microrobots were used to target and kill cancer cells via localized magnetic oscillations, resulting in magnetolysis of the cancer cells. The magnetic microrobots were selectively moved to Hepatocarcinoma cells (HepG2 cells) using a custom magnetic system which applied rotating magnetic fields. After internalization of the microrobots by the cancer cells, magnetic oscillation of varying dosages was applied, resulting in cell death.

Identifiers

PMID39421400
PMCPMC11484216

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.