ReviewTherapeutic advances in gastroenterology2024
Exploring the management and treatment of IBD from the perspective of psychological comorbidities.
Review in Therapeutic advances in gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Health Mindset in Pediatric Inflammatory Bowel Disease: Exploring the Relationship Between Health Mindset and Key Physical and Psychosocial Outcomes.Children (Basel, Switzerland) · 2026Article
- The impact of nurse-led care in inflammatory bowel disease management: a systematic review.BMC nursing · 2026Article
- Gut-brain axis: biological correlations between inflammatory bowel disease and anxiety or depressive disorders - a scoping review of reviews.BMC psychiatry · 2026Article
- Evaluation of Needs for Chronic Disease Management Services in Patients with Inflammatory Bowel Disease Based on the Kano Model: A Cross‑Sectional Study.Patient preference and adherence · 2026Article
- Role of enteral nutrition in the clinical care, management, and quality of life of patients with inflammatory bowel disease.Frontiers in nutrition · 2026Article
- Social alienation in patients with inflammatory bowel diseases: A latent profile analysis.International journal of nursing sciences · 2025Article
- Resilience and Self-Care in Patients with Inflammatory Bowel Disease: A Multicentre Cross-Sectional Study in Outpatient Settings.Journal of clinical medicine · 2025Article
- Gender Differences in Coping Strategies and Life Satisfaction Following Cognitive-Behavioral and Mindfulness-Based Intervention for Crohn's Disease: A Randomized Controlled Trial.Journal of clinical medicine · 2025Article
- Emotional Disturbances and Crohn's Disease.Clinical practice and epidemiology in mental health : CP & EMH · 2025Review
- The impact of depression, anxiety and stress on self-care in inflammatory bowel disease: a systematic review.Annals of gastroenterologyReview
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of anxiety, depression, and other psychological comorbidities among patients with inflammatory bowel disease (IBD) significantly exceeds that of the general population. Moreover, a bidirectional relationship exists between psychological comorbidities and IBD. This intricate interplay has substantial clinical implications, impacting treatment adherence, therapeutic efficacy, and disease recurrence rates. In this review, we explore the multifaceted mechanisms through which psychological factors influence IBD progression, treatment response, and prognosis. Specifically, we delve into the involvement of the hypothalamic-pituitary-adrenal axis, autonomic nervous system, enteric nervous system, microbiota-gut-brain axis, systemic inflammatory cytokines, and immune cell function. Additionally, we discuss the potential benefits of antidepressant therapy in mitigating IBD risk and the role of psychotropic drugs in reducing peripheral inflammation. Recognizing and addressing psychological comorbidity is pivotal in comprehensive IBD management. We advocate for the integration of biopsychosocial approaches into IBD treatment strategies, emphasizing the need for innovative psychological interventions as adjuncts to conventional therapies. Rigorous research investigating the impact of antidepressants and behavioral interventions on IBD-specific outcomes may herald a paradigm shift in IBD management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.