Evidence map›Paper›PMID 39420912›Full record

ArticleArchives of endocrinology and metabolism2024

Use of transient elastography for hepatic steatosis and fibrosis evaluation in patients with subclinical hypothyroidism.

Milena Tauil Auad Noronha Santos, Cristiane Alves Villela-Nogueira, Nathalie Carvalho Leite, Patrícia de Fátima Dos Santos Teixeira, Marcus Vinicius Leitão de Souza

Abstract read
In one paragraph

Article in Archives of endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Milena Tauil Auad Noronha SantosUniversidade Federal do Rio de Janeiro Hospital Universitário Clementino Fraga Filho Divisão de Endocrinologia Rio de JaneiroRJ Brasil Divisão de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.ORCID https://orcid.org/0000-0001-6008-1584
Cristiane Alves Villela-NogueiraUniversidade Federal do Rio de Janeiro Hospital Universitário Clementino Fraga Filho Divisão de Hepatologia Rio de JaneiroRJ Brasil Divisão de Hepatologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.ORCID https://orcid.org/0000-0003-1355-2368
Nathalie Carvalho LeiteUniversidade Federal do Rio de Janeiro Hospital Universitário Clementino Fraga Filho Divisão de Hepatologia Rio de JaneiroRJ Brasil Divisão de Hepatologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.ORCID https://orcid.org/0000-0001-9066-0405
Patrícia de Fátima Dos Santos TeixeiraUniversidade Federal do Rio de Janeiro Hospital Universitário Clementino Fraga Filho Divisão de Endocrinologia Rio de JaneiroRJ Brasil Divisão de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.ORCID https://orcid.org/0000-0001-8859-6387
Marcus Vinicius Leitão de SouzaUniversidade Federal do Rio de Janeiro Hospital Universitário Clementino Fraga Filho Divisão de Endocrinologia Rio de JaneiroRJ Brasil Divisão de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.ORCID https://orcid.org/0000-0002-9901-6138

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the association between subclinical hypothyroidism and hepatic steatosis and fibrosis using the noninvasive diagnostic methods transient hepatic elastography (TE) and controlled attenuation parameter (CAP) in patients with subclinical hypothyroidism. Subjects and methods: This was a cross-sectional study including women with confirmed spontaneous subclinical hypothyroidism and an age- and body mass index (BMI)-matched control group without thyroid disease or circulating antithyroperoxidase (anti-TPO) antibodies. Exclusion criteria were age > 65 years, thyroid-stimulating hormone (TSH) > 10.0 mIUI/L, BMI ≥ 35 kg/m Results: Of 68 women enrolled, 27 were included in the subclinical hypothyroidism group and 41 in the control group. Advanced steatosis (S3) was more frequent in the subclinical hypothyroidism group (25.9% Conclusion: The results of this study strengthen the hypothesis that hepatic steatosis is associated with autoimmune (positive anti-TPO) subclinical hypothyroidism, independently from BMI. However, subclinical hypothyroidism alone does not appear to be associated with a significantly increased risk of hepatic fibrosis.

Indexed as

Elasticity Imaging TechniquesFatty LiverHypothyroidismLiver CirrhosisAdultBody Mass IndexCase-Control StudiesCross-Sectional StudiesFemaleHumansLiverMiddle Agedfatty livermetabolic diseasesnonalcoholic fatty liver diseasesubclinical hypothyroidismTransient elastography

Identifiers

PMID39420912
PMCPMC11460959

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.