Evidence map›Paper›PMID 39420509›Full record

ArticlePediatric blood & cancer2025

Prevent Acute Chest Syndrome checklist (PACScheck): A quality improvement initiative to reduce acute chest syndrome.

Kerry Morrone, Kaitlin Strumph, Catherine Pisacano, Jessica Briggs, Rachelle Zipper, Bhaumik B Patel, Susanna Chang, Wen-Ling Kyon, Kristen Ronca, Miranda Abyazi and 7 more

Abstract read
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In one paragraph

Article in Pediatric blood & cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kerry MorroneDepartment of Pediatrics, Children's Hospital at Montefiore Bronx, New York, USA.ORCID https://orcid.org/0000-0003-2933-7961
Kaitlin StrumphDepartment of Pediatrics, Children's Hospital at Montefiore Bronx, New York, USA.ORCID https://orcid.org/0000-0002-5814-1004
Catherine PisacanoDepartment of Pediatrics, Children's Hospital at Montefiore Bronx, New York, USA.
Jessica BriggsDepartment of Pediatrics, Children's Hospital at Montefiore Bronx, New York, USA.
Rachelle ZipperDepartment of Pediatrics, Children's Hospital at Montefiore Bronx, New York, USA.ORCID https://orcid.org/0000-0002-4219-0514
Bhaumik B PatelNew York University Langone Health, New York, USA.
Susanna ChangDepartment of Pediatrics, Children's Hospital at Montefiore Bronx, New York, USA.
Wen-Ling KyonDepartment of Pediatrics, Children's Hospital at Montefiore Bronx, New York, USA.
Kristen RoncaDepartment of Pediatrics, Children's Hospital at Montefiore Bronx, New York, USA.ORCID https://orcid.org/0000-0002-2405-7808
Miranda AbyaziDepartment of Pediatrics, Children's Hospital at Montefiore Bronx, New York, USA.
Geoffrey ChengDepartment of Pediatrics, University of California San Francisco, San Francisco, USA.
Leya SchwartzDepartment of Pediatrics, St. Joseph Health, Renton, Washington, USA.
Jennifer De Los SantosDepartment of Pediatrics, Children's Hospital at Montefiore Bronx, New York, USA.
Janine KeenanDepartment of Pediatrics, Children's Hospital at Montefiore Bronx, New York, USA.
Marina ReznikDepartment of Pediatrics, Children's Hospital at Montefiore Bronx, New York, USA.
Deepa ManwaniDepartment of Pediatrics, Children's Hospital at Montefiore Bronx, New York, USA.ORCID https://orcid.org/0000-0003-1057-1811
Michael L RinkeDepartment of Pediatrics, Children's Hospital at Montefiore Bronx, New York, USA.

Funding

Einstein-Montefiore Clinical and Translational Science Award HubUM1TR004400 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Jessica Kahn, Mimi Y Kim · 2023 to 2026
$17.3M
AHRQ HHS K12 HS026396Empire Clinical Research Investigators ProgramEXPLORE Scholar-Agency for Healthcare Research and Quality/Patient-Centered Outcomes Research Institute (AHRQ/PCORI) K12 career development awardNCATS NIH HHS UM1 TR004400NIH/National Center for Advancing Translational Science (NCATS) Einstein-Montefiore CTSA 1UM1TR004400
6 · The paper itself

Abstract

backgroundAcute chest syndrome (ACS) is a life-threatening complication of sickle cell disease (SCD). The Prevent Acute Chest Syndrome checklist (PACScheck) was created to drive appropriate ordering of opioids, incentive spirometry (IS), intravenous fluids (IVF), evaluation of oxygen desaturation, and bronchodilator use.

objectivesDecrease the development of ACS by 5% in a hospitalized pediatric SCD population.

methodsA multidisciplinary team conducted a quality improvement (QI) project between April 2020 and August 2021 on an inpatient pediatric hematology unit. At-risk hospitalizations were patients with SCD who did not have ACS upon hospital admission. PACScheck was implemented and weekly run charts assessed documentation. Process control (p) charts, geometric control (g) charts, and chi-square tests assessed checklist process measures pre- and post-PACScheck. G chart assessed the number of encounters between ACS events.

resultsA total of 483 at-risk hospitalizations were identified in the 12 months prior and 363 during the study period. A g chart demonstrated that fewer encounters developed ACS during PACScheck. A p chart demonstrated that IS documentation increased during PACScheck. A run chart of PACScheck documentation demonstrated a median of 100% documentation at least once per hospitalization during the last six months of the intervention.

conclusionDevelopment of ACS can be reduced by implementing a best-practices checklist (PACScheck) on an inpatient pediatric hematology unit with a multidisciplinary team.

Indexed as

Acute Chest SyndromeAnemia, Sickle CellChecklistQuality ImprovementAdolescentChildFemaleFollow-Up StudiesHospitalizationHumansMalePrognosisOutcomes researchsickle cell diseasesupport care

Identifiers

PMID39420509
PMCPMC11584302

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.