Evidence map›Paper›PMID 39420412›Full record

ArticleTrials2024

Preparing for responsive management versus preparing for renal dialysis in multimorbid older people with advanced chronic kidney disease (Prepare for Kidney Care): Study protocol for a randomised controlled trial.

Jo Worthington, Alexandra Soundy, Jessica Frost, Leila Rooshenas, Stephanie J MacNeill, Alba Realpe Rojas, Kirsty Garfield, Yumeng Liu, Karen Alloway, Yoav Ben-Shlomo and 21 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Jo Worthington *Bristol Trials Centre, Bristol Medical School, University of Bristol, 1-5 Whiteladies Road, Bristol, BS8 1NU, UK.
Alexandra Soundy *Bristol Trials Centre, Bristol Medical School, University of Bristol, 1-5 Whiteladies Road, Bristol, BS8 1NU, UK.
Jessica FrostBristol Trials Centre, Bristol Medical School, University of Bristol, 1-5 Whiteladies Road, Bristol, BS8 1NU, UK.
Leila RooshenasPopulation Health Sciences, Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.
Stephanie J MacNeillBristol Trials Centre, Bristol Medical School, University of Bristol, 1-5 Whiteladies Road, Bristol, BS8 1NU, UK.
Alba Realpe RojasPopulation Health Sciences, Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.
Kirsty GarfieldBristol Trials Centre, Bristol Medical School, University of Bristol, 1-5 Whiteladies Road, Bristol, BS8 1NU, UK.
Yumeng LiuBristol Trials Centre, Bristol Medical School, University of Bristol, 1-5 Whiteladies Road, Bristol, BS8 1NU, UK.
Karen AllowayNorth Bristol NHS Trust, Southmead Hospital, Bristol, BS10 5NB, UK.
Yoav Ben-ShlomoPopulation Health Sciences, Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.
Aine BurnsUCL Department of Nephrology, Royal Free Hospital, University College, London, NW3 2QG, UK.
Joseph ChilcotInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, WC2R 2LS, UK.
Jos DarlingPublic and Patient Involvement Representative, London, UK.
Simon DaviesInstitute for Science and Technology in Medicine, Keele University, Keele, ST5 5BG, UK.
Ken FarringtonRenal Unit, East and North Hertfordshire NHS Trust, Coreys Mill Lane, Stevenage, SG1 4AB, UK.
Andrew GibsonARC West, Whitefriars, Lewins Mead, Bristol, BS1 2NT, UK.
Samantha HusbandsPopulation Health Sciences, Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.
Richard HuxtablePopulation Health Sciences, Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.
Helen McNallyNorth Bristol NHS Trust, Southmead Hospital, Bristol, BS10 5NB, UK.
Emma MurphyCentre for Care Excellence, Coventry University and University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
Fliss E M MurtaghWolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Hull, HU6 7RX, UK.
Hugh RaynerRenal Unit, Birmingham Heartlands Hospital, Bordesley Green E, Birmingham, B9 5SS, UK.
Caoimhe T RiceBristol Trials Centre, Bristol Medical School, University of Bristol, 1-5 Whiteladies Road, Bristol, BS8 1NU, UK.
Paul RoderickFaculty of Medicine, University of Southampton, University Road, Southampton, SO17 1BJ, UK.
Chris SalisburyPopulation Health Sciences, Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.
Jodi TaylorBristol Trials Centre, Bristol Medical School, University of Bristol, 1-5 Whiteladies Road, Bristol, BS8 1NU, UK.
Helen WintonBristol Trials Centre, Bristol Medical School, University of Bristol, 1-5 Whiteladies Road, Bristol, BS8 1NU, UK.
Jenny DonovanPopulation Health Sciences, Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.
Joanna CoastPopulation Health Sciences, Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.
J Athene LaneBristol Trials Centre, Bristol Medical School, University of Bristol, 1-5 Whiteladies Road, Bristol, BS8 1NU, UK.
Fergus J CaskeyPopulation Health Sciences, Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK. Fergus.caskey@bristol.ac.uk.ORCID http://orcid.org/0000-0002-5199-3925

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD) prevalence is steadily increasing, in part due to increased multimorbidity in our aging global population. When progression to kidney failure cannot be avoided, people need unbiased information to inform decisions about whether to start dialysis, if or when indicated, or continue with holistic person-centred care without dialysis (conservative kidney management). Comparisons suggest that while there may be some survival benefit from dialysis over conservative kidney management, in people aged 80 years and over, or with multiple health problems or frailty, this may be at the expense of quality of life, hospitalisations, symptom burden and preferred place of death. Prepare for Kidney Care aims to compare preparation for a renal dialysis pathway with preparation for a conservative kidney management pathway, in relation to quantity and quality of life in multimorbid, frail, older people with advanced CKD.

methodsThis is a two-arm, superiority, parallel group, non-blinded, individual-level, multi-centre, pragmatic trial, set in United Kingdom National Health Service (NHS) kidney units. Patients with advanced CKD (estimated glomerular filtration rate < 15 mL/min/1.73 m DISCUSSION: This randomised study is designed to provide high-quality evidence for frail, multimorbid, older patients with advanced CKD choosing between preparing for dialysis or conservative kidney management, and healthcare professionals and policy makers planning the related services.

trial registrationISRCTN, ISRCTN17133653 ( https://doi.org/10.1186/ISRCTN17133653 ). Registered 31 May 2017.

Indexed as

MultimorbidityPragmatic Clinical Trials as TopicQuality of LifeRenal DialysisRenal Insufficiency, ChronicAgedAged, 80 and overAge FactorsEquivalence Trials as TopicFemaleFrail ElderlyFrailtyGlomerular Filtration RateHumansMaleMulticenter Studies as TopicAdvance care planningChronic kidney diseaseConservative kidney managementDialysisIntegrated qualitative researchKidney failurePalliative careQuality-adjusted life yearsRandomised controlled trialSupportive care

Identifiers

PMID39420412
PMCPMC11487988

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.