Evidence map›Paper›PMID 39420388›Full record

ArticleEuropean journal of medical research2024

The role of parental consanguinity and familial aggregation in development of multiple sclerosis: a case-control study.

Saeed Vaheb, Mohammad Yazdan Panah, Alireza Afshari-Safavi, Elham Moases Ghaffary, Aysa Shaygannejad, Vahid Shaygannejad, Omid Mirmosayyeb

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Saeed VahebIsfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammad Yazdan PanahStudents Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Alireza Afshari-SafaviDepartment of Biostatistics and Epidemiology, Faculty of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Elham Moases GhaffaryIsfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Aysa ShaygannejadIsfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Vahid ShaygannejadIsfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. v.shaygannejad@gmail.com.
Omid MirmosayyebIsfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral studies pointed out the importance of genetic risk factors such as parental consanguinity (PC) and familial multiple sclerosis (FMS) in the risk of MS. This study aimed to investigate the PC and FMS among people with MS (pwMS) in Isfahan, Iran.

methodsThis case-control study was conducted on pwMS from the MS clinic of Kashani Hospital, Isfahan, Iran, in October 2023. A group of healthy controls (HC) were also recruited. Data on demographic and clinical characteristics and history of PC and FMS were collected from participants. The relationships between PC, FMS, and developing MS were assessed using multinomial logistic regression analysis. The odds ratio (OR) with a 95% confidence interval (CI) was computed.

resultsA total number of 4264 pwMS and 400 HCs were included. The prevalence of PC and FMS among pwMS were 29.3% and 24%, respectively. Multinomial logistic regression adjusted for age and sex indicated that the odds of developing MS were significantly associated with a history of PC (OR = 3.03, 95% CI 2.23 to 4.13, p < 0.001) and FMS (OR = 5.42, 95% CI 3.51 to 8.38, p < 0.001).

conclusionPC and FMS can increase the risk of developing MS. They should be considered along with other risk factors for developing MS. A comprehensive conclusion requires further research.

Indexed as

ConsanguinityMultiple SclerosisAdultCase-Control StudiesFemaleGenetic Predisposition to DiseaseHumansIranMaleMiddle AgedParentsRisk FactorsYoung AdultFamilial multiple sclerosisMultiple sclerosisParental consanguinity

Identifiers

PMID39420388
PMCPMC11488231

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.