Evidence map›Paper›PMID 39420345›Full record

ArticleCardiovascular diabetology2024

Endothelial cells derived extracellular vesicles promote diabetic arterial calcification via circ_0008362/miR-1251-5p/Runx2 axial.

Xiao Lin, Sha-Qi He, Su-Kang Shan, Feng Xu, Feng Wu, Fu-Xing-Zi Li, Ming-Hui Zheng, Li-Min Lei, Jia-Yue Duan, Yun-Yun Wu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xiao Lin *Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Sha-Qi He *Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Su-Kang ShanNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China.
Feng XuNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China.
Feng WuDepartment of Pathology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China.
Fu-Xing-Zi LiNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China.
Ming-Hui ZhengNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China.
Li-Min LeiNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China.
Jia-Yue DuanNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China.
Yun-Yun WuNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China.
Yan-Lin WuNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China.
Ke-Xin TangNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China.
Rong-Rong CuiNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China.
Bei HuangDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Jun-Jie YangDepartment of Radiology, The Second Affiliated Hospital of Xinjiang Medical University, Ürümqi, 830054, China.
Xiao-Bo LiaoDepartment of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Jun LiuDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China. junliu123@csu.edu.cn.
Ling-Qing YuanNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China. allenylq@csu.edu.cn.

Funding

Fundamental Research Funds for Central Universities of the Central South University 2024ZZTS0883Key Project of Research and Development Plan of Hunan Province 2020SK2078National Natural Science Foundation of China 82100944National Natural Science Foundation of China 82370892
6 · The paper itself

Abstract

introductionArterial calcification, an independent predictor of cardiovascular events, increases morbidity and mortality in patients with diabetes mellitus (DM), but its mechanisms remain unclear. Extracellular vesicles (EVs) play an important role in intercellular communication. The study investigates the role and potential mechanisms of EVs derived from endothelial cells (ECs) in regulating vascular smooth muscle cell (VSMC) calcification under high glucose (HG) condition, with a goal of developing effective prevention and treatment strategies for diabetic arterial calcification.

resultsThe results showed that EVs derived from HG induced ECs (EC

conclusionsOur findings suggested that circ_0008362 was enriched in EVs derived from ECs and promoted VSMC calcification under HG conditions, both by sponging miR-1251-5p to upregulate Runx2 expression and through direct interaction with Runx2. Furthermore, elevated levels of plasma EVs circ_0008362 were associated with more severe coronary and aorta artery calcification in patients with DM. These results may serve as a potential prevention and therapeutic target for diabetic arterial calcification.

Indexed as

Core Binding Factor Alpha 1 SubunitDiabetic AngiopathiesEndothelial CellsMicroRNAsMuscle, Smooth, VascularMyocytes, Smooth MuscleSignal TransductionVascular CalcificationAnimalsAortic DiseasesCells, CulturedDisease Models, AnimalExtracellular VesiclesGene Expression RegulationHumansMaleCore Binding Factor Alpha 1 SubunitMicroRNAsRNA, CircularRunx2 protein, mouseArterial calcificationCirc_0008362Diabetes mellitusEndothelial cellsExtracellular vesiclesVascular smooth muscle cells

Identifiers

PMID39420345
PMCPMC11488141

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.