Evidence map›Paper›PMID 39420328›Full record

ArticleJournal of nanobiotechnology2024

Highly integrated, self-powered and activatable bipedal DNA nanowalker for imaging of base excision repair in living cells.

Rongji Lai, Xianghe Pan, Yingfeng Qin, Jialin Liang, Liu Wu, Meiyu Dong, Jia Chen, Jin-Wen Liu

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rongji LaiKey Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of Education, Key Laboratory of Biological Molecular Medicine Research, Education Department of Guangxi Zhuang Autonomous Region, School of Basic Medical Sciences, Guangxi Medical University, Nanning, 530021, P.R. China.
Xianghe PanKey Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of Education, Key Laboratory of Biological Molecular Medicine Research, Education Department of Guangxi Zhuang Autonomous Region, School of Basic Medical Sciences, Guangxi Medical University, Nanning, 530021, P.R. China.
Yingfeng QinKey Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of Education, Key Laboratory of Biological Molecular Medicine Research, Education Department of Guangxi Zhuang Autonomous Region, School of Basic Medical Sciences, Guangxi Medical University, Nanning, 530021, P.R. China. qinyingfeng@sr.gxmu.edu.cn.
Jialin LiangKey Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of Education, Key Laboratory of Biological Molecular Medicine Research, Education Department of Guangxi Zhuang Autonomous Region, School of Basic Medical Sciences, Guangxi Medical University, Nanning, 530021, P.R. China.
Liu WuKey Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of Education, Key Laboratory of Biological Molecular Medicine Research, Education Department of Guangxi Zhuang Autonomous Region, School of Basic Medical Sciences, Guangxi Medical University, Nanning, 530021, P.R. China.
Meiyu DongKey Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of Education, Key Laboratory of Biological Molecular Medicine Research, Education Department of Guangxi Zhuang Autonomous Region, School of Basic Medical Sciences, Guangxi Medical University, Nanning, 530021, P.R. China.
Jia ChenCAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, P.R. China.
Jin-Wen LiuKey Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of Education, Key Laboratory of Biological Molecular Medicine Research, Education Department of Guangxi Zhuang Autonomous Region, School of Basic Medical Sciences, Guangxi Medical University, Nanning, 530021, P.R. China. jinwenliu@hnu.edu.cn.

Funding

Guangxi Natural Science Foundation 2024GXNSFAA010208Guangxi Science and Technology Major Program AA24011005National Natural Science Foundation of China 22266007Open Project of Key Laboratory of Longevity and Aging-related Diseases (Guangxi Medical University), Ministry of Education KLLAD202302Undergraduate Innovation and Entrepreneurship Training Program Project 202110598009
6 · The paper itself

Abstract

DNA walkers have attracted considerable attention in biosensing and bioimaging. Compared with the conventional single leg-based DNA walker, the bipedal DNA walker has remarkable advantages, with improved sensitivity and fast kinetics, and can work efficiently in a crowded cellular environment. However, most reported bipedal DNA walkers are powered by exogenous supplementation, and elaborate DNA sequence designs, auxiliary additives or extra carriers are often needed. A highly integrated bipedal DNA walker that can address robustness, sensitivity and consistency issues in a single system is highly desirable but remains a great challenge. We herein report a novel bipedal DNA nanowalker system through simple assembly of a DNA substrate, hairpin functionalized-AuNPs (AuNPs-H2), and a blocked Mn

Indexed as

DNADNA, CatalyticDNA RepairGoldManganese CompoundsMetal NanoparticlesBiosensing TechniquesDNA-(Apurinic or Apyrimidinic Site) LyaseExcision RepairHeLa CellsHumansNanostructuresOxidesDNADNA-(Apurinic or Apyrimidinic Site) LyaseDNA, CatalyticGoldManganese Compoundsmanganese dioxideOxidesAccelerated reaction kineticsAmplified fluorescence imagingBase excision repairBipedal DNA nanowalkerHighly integrated DNA machine

Identifiers

PMID39420328
PMCPMC11487878

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.