ArticleNature metabolism2024
Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology.
Abstract read
In one paragraph
Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Nutrient and non-nutrient regulators of insulin secretion.Nature reviews. Endocrinology · 2026Review
- FAM234A acts as a switch between Th17 and Treg cell fate decisions that control inflammatory bowel disease.Cellular & molecular immunology · 2026Article
- Calcium signaling pathway implicates a shared genetic basis between psychiatric and cardiovascular diseases.Translational psychiatry · 2026Article
- Maternal and fetal genetic predispositions to insulin deficiency and resistance affect fetal growth through distinct pathways.Diabetologia · 2026Article
- The C-terminal region of TENT5 proteins drives ER-associated mRNA polyadenylation via FNDC3 interaction.Cell reports · 2026Article
- Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application.MedComm · 2026Review
- Converging TCF7L2 and CDKAL1 pathways in the pathogenesis of type 2 diabetes mellitus.Acta diabetologica · 2026Review
- Functional ADAM12 variants modulate proteolytic activity and influence metabolic traits.Scientific reports · 2026Article
- Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes.Nature communications · 2025Article
- The role of the beta cell in type 2 diabetes: new findings from the last 5 years.Diabetologia · 2025Review
- HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes.Cell metabolism · 2025Article
- Alternative Splicing Regulation in Metabolic Disorders.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors.
A L Madsen *Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen (UCPH), Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2734-5183
S Bonàs-Guarch *Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID http://orcid.org/0000-0002-2085-7488
S GheibiDepartment of Clinical Sciences, Unit of Molecular Metabolism, Lund University, Malmö, Sweden.
R PrasadDepartment of Clinical Sciences, Unit of Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-4400-6741
J VangipurapuInstitute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0001-6657-2659
V AhujaInstitute for Molecular Medicine Finland and Research Program of Clinical and Molecular Medicine, University of Helsinki, Helsinki, Finland.
L R CataldoNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen (UCPH), Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1225-414X
O DwivediInstitute for Molecular Medicine Finland and Research Program of Clinical and Molecular Medicine, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-8670-7717
G HatemDepartment of Clinical Sciences, Unit of Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden.
G AtlaCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
M Guindo-MartínezNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen (UCPH), Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-8099-9170
A M JørgensenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen (UCPH), Copenhagen, Denmark.
A E JonssonNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen (UCPH), Copenhagen, Denmark.
I Miguel-EscaladaCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
S HassanNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen (UCPH), Copenhagen, Denmark.ORCID http://orcid.org/0009-0000-9751-0098
A LinnebergCenter for Clinical Research and Prevention, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-0994-0184
Tarunveer S AhluwaliaSteno Diabetes Center Copenhagen, Herlev, Denmark.ORCID http://orcid.org/0000-0002-7464-3354
T DrivsholmCenter for Clinical Research and Prevention, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.
O PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen (UCPH), Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-3321-3972
T I A SørensenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen (UCPH), Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4821-430X
A AstrupNovo Nordisk Fonden, Hellerup, Denmark.ORCID http://orcid.org/0000-0001-8968-8996
D WitteInstitut for Folkesundhed-Epidemiologi, Aarhus University, Aarhus, Denmark.
P DammCenter for Pregnant Women with Diabetes and Department of Gynecology, Fertility, and Obstetrics and Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-2067-5246
T D ClausenCenter for Pregnant Women with Diabetes and Department of Gynecology, Fertility, and Obstetrics and Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5585-2153
E MathiesenCenter for Pregnant Women with Diabetes, Department of Nephrology and Endocrinology and Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
T H PersNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen (UCPH), Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-0207-4831
R J F LoosNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen (UCPH), Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-8532-5087
L HakasteInstitute for Molecular Medicine Finland and Research Program of Clinical and Molecular Medicine, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-9212-3873
M FexDepartment of Clinical Sciences, Unit of Molecular Metabolism, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0003-0675-7576
N GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen (UCPH), Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5526-1070
T TuomiDepartment of Clinical Sciences, Unit of Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-8306-6202
M LaaksoInstitute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-3394-7749
H MulderDepartment of Clinical Sciences, Unit of Molecular Metabolism, Lund University, Malmö, Sweden.
J FerrerCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. jorge.ferrer@crg.eu.ORCID http://orcid.org/0000-0002-5959-5729
T HansenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen (UCPH), Copenhagen, Denmark. torben.hansen@sund.ku.dk.ORCID http://orcid.org/0000-0001-8748-3831
Funding
Genetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2MIdentifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6MTargeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3MGenetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2MIdentifying Genes for Type 2 Diabetes:FUSIONR01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2003 to 2025
$6.7MIdentifying Genes for Type 2 Diabetes: FUSIONR56DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L · 2008 to 2008
$500kIntramural NIH HHS ZIA HG000024Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) PMP21/00067NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK093757NIDDK NIH HHS R56 DK062370NIDDK NIH HHS U01 DK062370Novo Nordisk Fonden (Novo Nordisk Foundation) NNF18OC0034532Wellcome TrustWellcome Trust (Wellcome) WT101033
Abstract
The genetics of β-cell function (BCF) offer valuable insights into the aetiology of type 2 diabetes (T2D)
Indexed as
Diabetes Mellitus, Type 2Genome-Wide Association StudyInsulin-Secreting CellsGenetic Predisposition to DiseaseGlucoseGlucose Tolerance TestHumansInsulinInsulin SecretionPolymorphism, Single NucleotideGlucoseInsulin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.