Evidence map›Paper›PMID 39420137›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2024

Hypoxia drives estrogen receptor β-mediated cell growth via transcription activation in non-small cell lung cancer.

Qi Su, Kun Chen, Jiayan Ren, Yu Zhang, Xu Han, Sze Wei Leong, Jingjing Wang, Qing Wu, Kaihui Tu, Ammar Sarwar and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qi SuSchool of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, Shaanxi Province, 710061, P. R. China.
Kun ChenSchool of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, Shaanxi Province, 710061, P. R. China.
Jiayan RenSchool of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, Shaanxi Province, 710061, P. R. China.
Yu ZhangSchool of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, Shaanxi Province, 710061, P. R. China.
Xu HanSchool of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, Shaanxi Province, 710061, P. R. China.
Sze Wei LeongDepartment of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.
Jingjing WangSchool of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, Shaanxi Province, 710061, P. R. China.
Qing WuSchool of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, Shaanxi Province, 710061, P. R. China.
Kaihui TuSchool of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, Shaanxi Province, 710061, P. R. China.
Ammar SarwarSchool of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, Shaanxi Province, 710061, P. R. China.
Yanmin ZhangSchool of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, Shaanxi Province, 710061, P. R. China. zhang2008@mail.xjtu.edu.cn.ORCID 0000-0001-7307-9408

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) is a highly malignant tumor with a poor prognosis. Hypoxia conditions affect multiple cellular processes promoting the adaptation and progression of cancer cells via the activation of hypoxia-inducible factors (HIF) and subsequent transcription activation of their target genes. Preliminary studies have suggested that estrogen receptor β (ERβ) might play a promoting role in the progression of NSCLC. However, the precise mechanisms, particularly its connection to HIF-1α-mediated modulation under hypoxia, remain unclear. Our findings demonstrated that the overexpression of ERβ, not ERα, increased cell proliferation and inhibition of apoptosis in NSCLC cells and xenografts. Tissue microarray staining revealed a strong correlation between the protein expression of HIF-1α and ERβ. HIF-1α induced ERβ gene transcription and protein expression in CoCl

Indexed as

Carcinoma, Non-Small-Cell LungCell ProliferationEstrogen Receptor betaGene Expression Regulation, NeoplasticHypoxia-Inducible Factor 1, alpha SubunitLung NeoplasmsTranscriptional ActivationAnimalsApoptosisCell HypoxiaCell Line, TumorFemaleHumansMiceMice, NudePromoter Regions, GeneticESR2 protein, humanEstrogen Receptor betaHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitEstrogen receptor βFulvestrantHypoxia-inducible factor 1αLW6Non-small cell lung cancer

Identifiers

PMID39420137

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.