Evidence map›Paper›PMID 39420102›Full record

ArticleScientific reports2024

Frugal engineering-inspired wearable augmented reality goggle system enables fluorescence-guided cancer surgery.

Leonid Shmuylovich, Christine M O'Brien, Karen Nwosu, Samuel Achilefu

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Leonid ShmuylovichBiophotonics Research Center, Department of Radiology, Washington University in Saint Louis School of Medicine, Saint Louis, MO, USA. shmuylol@wustl.edu.
Christine M O'BrienBiophotonics Research Center, Department of Radiology, Washington University in Saint Louis School of Medicine, Saint Louis, MO, USA.
Karen NwosuBiophotonics Research Center, Department of Radiology, Washington University in Saint Louis School of Medicine, Saint Louis, MO, USA.
Samuel AchilefuDepartment of Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, TX, USA. samuel.achilefu@utsouthwestern.edu.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
The Center for Label-free Imagingand Multiscale Biophotonics (CLIMB)P41EB031772 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Stephen A Boppart · 2022 to 2026
$7.6M
NANOPHOTOSENSITIZERS FOR REGENERATIVE PHOTOTHERAPYR01CA260855 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2021 to 2025
$3.5M
Training OPportunities in Translational Imaging Education and Research (TOP-TIER)T32EB021955 · NIBIB · WASHINGTON UNIVERSITY · PI Hongyu An, Joseph Edward Ippolito · 2017 to 2026
$2.4M
Imaging Goggles for Fluorescence-Guided SurgeryR01EB030987 · NIBIB · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL, BURAS, WILLIAM ROBINSON · 2021 to 2024
$2.1M
National Institutes of Health,United States R01EB030987National Institutes of Health,United States T32EB021955NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA260855NIBIB NIH HHS P41 EB031772NIBIB NIH HHS R01 EB030987NIBIB NIH HHS T32 EB021955
6 · The paper itself

Abstract

Disparities in surgical outcomes often result from subjective decisions dictated by surgical training, experience, and available resources. To improve outcomes, surgeons have adopted advancements in robotics, endoscopy, and intra-operative imaging including fluorescence-guided surgery (FGS), which highlights tumors and anatomy in real-time. However, technical, economic, and logistic challenges hinder widespread adoption of FGS beyond high-resource centers. To overcome these impediments, we combined laser diodes, Raspberry Pi cameras and computers, off-the-shelf optical components, and 3D-printed parts to make a battery-powered, compact, dual white light and NIR imaging system that has comparable performance to existing bulkier, pricier, and wall-powered technologies. We combined these components with off-the-shelf augmented reality (AR) glasses to create a fully-wearable fluorescence imaging AR Raspberry Pi-based goggle system (FAR-Pi) and validated performance in a pre-clinical cancer surgery model. Novel device design ensures distance-independent coalignment between real and augmented views. As an open-source, affordable, and adaptable system, FAR-Pi is poised to democratize access to FGS and improve health outcomes worldwide.

Indexed as

Augmented RealityNeoplasmsOptical ImagingSurgery, Computer-AssistedWearable Electronic DevicesAnimalsEquipment DesignFluorescenceHumansAugmented realityFluorescence guided surgeryOpen source hardwareRaspberry piWearable

Identifiers

PMID39420102
PMCPMC11487067

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.