Evidence map›Paper›PMID 39420083›Full record

ArticleMycopathologia2024

In Situ Expression of TNF-α and IL-10 in Human Dermatophytosis Lesions due to Trichophyton rubrum.

Ana Paula Carvalho Reis, Franciele Fernandes Correia, Giovanna Azevedo Celestrino, Carla Pagliari, Paulo Ricardo Criado, Pritesh Jaychand Lalwani, Gil Benard, Maria Gloria Teixeira Sousa

Abstract read
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In one paragraph

Article in Mycopathologia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ana Paula Carvalho ReisLaboratório de Investigação Médica LIM 53, Divisão de Clínica Dermatológica, Instituto de Medicina Tropical, Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, São Paulo, Brasil.
Franciele Fernandes CorreiaLaboratório de Investigação Médica LIM 53, Divisão de Clínica Dermatológica, Instituto de Medicina Tropical, Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, São Paulo, Brasil.
Giovanna Azevedo CelestrinoLaboratório de Investigação Médica LIM 53, Divisão de Clínica Dermatológica, Instituto de Medicina Tropical, Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, São Paulo, Brasil.
Carla PagliariLaboratório da Disciplina de Patologia de Moléstias Transmissíveis, Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brasil.
Paulo Ricardo CriadoFaculdade de Medicina do ABC, Santo André, São Paulo, Brasil.
Pritesh Jaychand LalwaniInstituto Leônidas e Maria Deane-ILMD/Fiocruz Amazônia, Manaus, AM, Brasil.
Gil BenardLaboratório de Investigação Médica LIM 53, Divisão de Clínica Dermatológica, Instituto de Medicina Tropical, Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, São Paulo, Brasil.
Maria Gloria Teixeira SousaLaboratório de Investigação Médica LIM 53, Divisão de Clínica Dermatológica, Instituto de Medicina Tropical, Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, São Paulo, Brasil. sousa.gloria@gmail.com.ORCID http://orcid.org/0000-0003-4157-1945

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo #2016/16369-1Fundação de Amparo à Pesquisa do Estado de São Paulo #2017/26208-8Fundação de Amparo à Pesquisa do Estado de São Paulo #2018/16146-8Fundação de Amparo à Pesquisa do Estado de São Paulo #2018/24175-8
6 · The paper itself

Abstract

Dermatophytosis is a very common superficial mycosis, but there are few studies about the human immune response to dermatophytes. We aim to analyze the in situ expression of TNF-α and IL-10 in human dermatophytosis. Expression of TNF-α and IL-10 were evaluated in skin samples from 10 patients with dermatophytosis and 12 healthy subjects using an immunohistochemistry assay. TNF-α and IL-10 were significantly elevated in lesions from patients with dermatophytosis compared to healthy controls. These data illustrate the balance of pro- and anti-inflammatory cytokines suggesting Trichophyton rubrum infection could control the local immune response.

Indexed as

ImmunohistochemistryInterleukin-10TineaTumor Necrosis Factor-alphaAdultAgedArthrodermataceaeFemaleHumansMaleMiddle AgedSkinTrichophytonYoung AdultIL10 protein, humanInterleukin-10Tumor Necrosis Factor-alphaDermatophytosisIL-10Immune responseTNF-αT. rubrum

Identifiers

PMID39420083

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.