Evidence map›Paper›PMID 39419768›Full record

ArticleTranslational behavioral medicine2024

Moving psychedelic-assisted therapies from promising research into routine clinical practice: Lessons from the field of implementation science.

Danielle R Adams, Heidi Allen, Ginger E Nicol, Leopoldo J Cabassa

Abstract read
In one paragraph

Article in Translational behavioral medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Trials, trips, and tribulations: pathways for implementing psychedelic therapy in Ireland.The international journal of neuropsychopharmacology · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Danielle R AdamsSchool of Social Work, College of Health Sciences, University of Missouri-Columbia, Columbia, MO 65211, USA.ORCID 0000-0002-3892-989X
Heidi AllenSchool of Social Work, Colombia.
Ginger E NicolDepartment of Psychiatry, Washington University School of Medicine in St. Louis, MO 63110, USA.ORCID 0000-0001-5823-6129
Leopoldo J CabassaBrown School of Social Work, Washington University in St. Louis, MO 63105, USA.ORCID 0000-0002-1872-4141

Funding

Using mHealth to optimize pharmacotherapy regimensP50MH115843 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Neil Krishan Aggarwal · 2018 to 2026
$12.7M
GWB MENTAL HEALTH SERVICE RESEARCH TRAININGT32MH019960 · NIMH · WASHINGTON UNIVERSITY · PI Leopoldo J Cabassa, Byron James Powell · 1995 to 2026
$11.1M
Early Stage Identification and Engagement to Reduce the Duration of Untreated Psychosis: Evaluating the Impact of Screening and Systematic CommunicationR01MH130354 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Yulia Landa · 2022 to 2026
$4.1M
OnTrackChile for First Episode PsychosisR01MH115502 · NIMH · UNIVERSIDAD DE O'HIGGINS · PI ALVARADO, RUBEN VLADIMIR, CABASSA, LEOPOLDO J · 2018 to 2022
$2.9M
Mentored Education for Dissemination and Implementation Science (MEDIS) ProgramR25DK123008 · NIDDK · WASHINGTON UNIVERSITY · PI BROWNSON, ROSS C, HAIRE-JOSHU, DEBRA · 2020 to 2024
$1.1M
Alkermes, IncCOMPASS pathwaysJoe and Sandy Samberg FoundationLB Pharmaceuticals, Inc.NIDDK NIH HHS R25 DK123008NIMH NIH HHS P50 MH115843NIMH NIH HHS R01 MH115502NIMH NIH HHS R01 MH130354NIMH NIH HHS R01MH130354NIMH NIH HHS T32 MH019960Steven and Alexandra Cohen FoundationUsona Institute
6 · The paper itself

Abstract

Psychedelics (e.g., 3,4-Methylenedioxymethamphetamine [MDMA], lysergic acid diethylamide [LSD], psilocybin) are molecules that have the potential to produce rapid therapeutic effects when paired with psychotherapy. Randomized clinical trials of psychedelic-assisted psychotherapy (PAT) have shown promising results for post-traumatic stress disorder (PTSD), depression, and substance use disorders. The U.S. Food and Drug Administration has acknowledged the promise of PAT, signaling potential approval of psilocybin-assisted therapy for depression by 2026. Given this timeline, implementation scientists must engage with PAT researchers, policymakers, and practitioners to think critically about bringing these promising new treatments into routine practice settings while maintaining quality and safety. This commentary aims to initiate a dialogue between implementation scientists and PAT researchers and practitioners on addressing these questions with a lens toward equity. Specifically, we discuss how the field of implementation science can support PAT stakeholders to accelerate the translational process from research into practice, focusing specifically on safety-net settings (i.e., Federally Qualified Health Centers and Veterans Affairs health systems) that serve historically marginalized populations. We use the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) Framework to illustrate five critical areas where implementation science can help move PAT from research into real-world practice. For each RE-AIM dimension, we highlight ways the field of implementation science can contribute tools (e.g., implementation strategies), methodologies (e.g., pragmatic hybrid implementation-effectiveness trials), and approaches (community-based participatory research) for establishing the safety, effectiveness, and accessibility of PAT for historically underserved communities.

Indexed as

HallucinogensImplementation SciencePsychotherapyDepressionHumansPsilocybinStress Disorders, Post-TraumaticSubstance-Related DisordersUnited StatesHallucinogensPsilocybinequityimplementation sciencemental healthpsilocybinpsychedelic-assisted therapysafety-net health settings

Identifiers

PMID39419768
PMCPMC11587814

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.