Evidence map›Paper›PMID 39419618›Full record

ArticleBMJ open2024

The chronic wound characterisation study and biobank: a study protocol for a prospective observational cohort investigation of bacterial community composition, inflammatory responses and wound-healing trajectories in non-healing wounds.

Anne Kristine Servais Iversen, Mads Lichtenberg, Blaine Gabriel Fritz, Isabel Díaz-Pinés Cort, Dania Firas Al-Zoubaidi, Hans Gottlieb, Klaus Kirketerp-Møller, Thomas Bjarnsholt, Tim Holm Jakobsen

Abstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Chinese herbal medicines · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anne Kristine Servais IversenCosterton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.ORCID 0009-0006-1095-6294
Mads LichtenbergCosterton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-0675-4554
Blaine Gabriel FritzCosterton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-2085-894X
Isabel Díaz-Pinés CortCosterton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-2599-3008
Dania Firas Al-ZoubaidiCosterton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.ORCID 0009-0001-7828-0618
Hans GottliebDepartment of Orthopaedic Surgery, Herlev Hospital, Herlev, Denmark.ORCID 0000-0003-2945-8392
Klaus Kirketerp-MøllerCopenhagen Wound Healing Centre, University Hospital of Copenhagen, Bispebjerg, Copenhagen, Denmark.ORCID 0000-0002-3248-8448
Thomas BjarnsholtCosterton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-8003-7414
Tim Holm JakobsenCosterton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark tholm@sund.ku.dk.ORCID 0000-0002-1671-2155

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChronic wounds affect 1%-2% of the global population, with rising incidence due to ageing and lifestyle-related diseases. Bacterial biofilms, found in 80% of chronic wounds, and scattered single-cell bacteria may hinder healing. Microbes are believed to negatively impact healing by exacerbating inflammation and host immune response. METHODS AND ANALYSIS: The primary objective of the chronic wound characterisation (CWC) study is to investigate chronic wounds through a prospective observational cohort study exploring bacterial community composition, inflammatory responses and the influence of bacteria on wound-healing trajectories. The CWC study will be investigated through two cohorts: the ETHICS AND DISSEMINATION: The study has been approved by the board of health ethics, Capital Region of Denmark, under protocol number H-20032214. The study findings will be disseminated through peer-reviewed publications and showcased at both national and international conferences and meetings within the domains of microbiology, wound healing and infection.

Indexed as

Biological Specimen BanksWound HealingBacteriaBiofilmsChronic DiseaseDebridementHumansInflammationMicrobiotaObservational Studies as TopicProspective StudiesResearch DesignRNA, Ribosomal, 16SSkin TransplantationWounds and InjuriesRNA, Ribosomal, 16SBacteriologyBiopsyChronic DiseaseInfectious DiseasesWound Management

Identifiers

PMID39419618
PMCPMC11487800

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.