Evidence map›Paper›PMID 39419533›Full record

ArticleAJNR. American journal of neuroradiology2024

Neuroimaging Correlates with Clinical Severity in Wilson Disease: A Multiparametric Quantitative Brain MRI.

Xiao-Zhong Jing, Gai-Ying Li, Yu-Peng Wu, Xiang-Zhen Yuan, Jia-Lin Chen, Shu-Hong Wang, Xiao-Ping Wang, Jian-Qi Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiao-Zhong JingFrom the Department of Neurology (X.-Z.J.), The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Gai-Ying LiShanghai Key Laboratory of Magnetic Resonance (G.-Y.L., Y-P.W., J-L.C., J-Q.L.), School of Physics and Electronic Science, East China Normal University, Shanghai, China.
Yu-Peng WuShanghai Key Laboratory of Magnetic Resonance (G.-Y.L., Y-P.W., J-L.C., J-Q.L.), School of Physics and Electronic Science, East China Normal University, Shanghai, China.
Xiang-Zhen YuanDepartment of Neurology (X.-Z.Y.), Weifang People's Hospital, Weifang, China.
Jia-Lin ChenShanghai Key Laboratory of Magnetic Resonance (G.-Y.L., Y-P.W., J-L.C., J-Q.L.), School of Physics and Electronic Science, East China Normal University, Shanghai, China.
Shu-Hong WangDepartment of Neurology (S.-H.W.), Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiao-Ping WangDepartment of Neurology (X.-P.W.), Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jian-Qi LiShanghai Key Laboratory of Magnetic Resonance (G.-Y.L., Y-P.W., J-L.C., J-Q.L.), School of Physics and Electronic Science, East China Normal University, Shanghai, China jqli@phy.ecnu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposePrevious studies have reported metal accumulation and microstructure changes in deep gray nuclei (DGN) in Wilson disease (WD). However, there are limited studies that investigate whether there is metal accumulation and microstructure changes in DGN of patients with WD with normal-appearing routine MRI. This study aimed to evaluate multiparametric changes in DGN of WD and whether the findings correlate with clinical severity in patients with WD. MATERIALS AND

methodsThe study enrolled 28 patients with WD (19 with neurologic symptoms) and 25 controls. Fractional anisotropy (FA), mean diffusivity (MD), and magnetic susceptibility in globus pallidus, pontine tegmentum, dentate nucleus, red nucleus, head of caudate nucleus, putamen, substantia nigra, and thalamus were extracted. Correlations between imaging data and the Unified Wilson's Disease Rating Scale (UWDRS) neurologic subitems were explored.

resultsFA, MD, and susceptibility values were higher in multiple DGN of patients with WD than controls (

conclusionsPatients with WD have increased FA, MD, and susceptibility values even before the lesion is morphologically apparent on routine MRI. The increased FA and susceptibility values correlate with clinical severity of WD.

Indexed as

Hepatolenticular DegenerationMagnetic Resonance ImagingSeverity of Illness IndexAdolescentAdultBrainChildFemaleHumansMaleNeuroimagingYoung Adult

Identifiers

PMID39419533
PMCPMC11543078

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.