Evidence map›Paper›PMID 39419456›Full record

ReviewFree radical biology & medicine2024

Mouse models used to test the role of reactive oxygen species in aging and age-related chronic diseases.

Hoang Van M Nguyen, Qitao Ran, Adam B Salmon, Ahn Bumsoo, Ying Ann Chiao, Shylesh Bhaskaran, Arlan Richardson

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Free radical biology & medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hoang Van M NguyenDepartment of Nutritional Sciences, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.
Qitao RanDepartment of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; VA South Texas Health Care System, San Antonio, TX, USA.
Adam B SalmonDepartment of Molecular Medicine, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; VA South Texas Health Care System, San Antonio, TX, USA.
Ahn BumsooGerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Ying Ann ChiaoAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Shylesh BhaskaranAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Arlan RichardsonDepartment of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA; VA Oklahoma Health Care System, Oklahoma City, OK, USA. Electronic address: Arlan-Richardson@ouhsc.edu.

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LEON LENCHIK · 2002 to 2026
$36.4M
TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6M
Membrane lipid peroxidation in pathogenesis of Alzheimer’s diseaseR01AG064078 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI RAN, QITAO · 2019 to 2023
$1.9M
The role of unacylated ghrelin on age-associated progressive muscle weakness and cachexia elicited by cancerR00AG064143 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI AHN, BUMSOO · 2022 to 2024
$839k
BLR&D Research Career Scientist Award ApplicationIK6BX005238 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI ARLAN G. RICHARDSON · 2020 to 2026
–
Effect of Necroptosis in Neurons on Neuroinflammation, Neuronal Function, and CognitionI01BX004538 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI FREEMAN, WILLARD M, RICHARDSON, ARLAN G. · 2019 to 2024
–
Investigation of Ferroptosis as a Therapeutic Target for ALSI01BX005906 · VA · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · PI RAN, QITAO · 2023 to 2025
–
BLRD VA I01 BX004538BLRD VA I01 BX005906BLRD VA IK6 BX005238NIA NIH HHS P30 AG013319NIA NIH HHS P30 AG021332NIA NIH HHS R00 AG064143NIA NIH HHS R01 AG064078
6 · The paper itself

Abstract

With the development of the technology to generate transgenic and knockout mice in the 1990s, investigators had a powerful tool to directly test the impact of altering a specific gene on a biological process or disease. Over the past three decades, investigators have used transgenic and knockout mouse models, which have altered expression of antioxidant genes, to test the role of oxidative stress/damage in aging and age-related diseases. In this comprehensive review, we describe the studies using transgenic and knockout mouse models to test the role of oxidative stress/damage in aging (longevity) and three age-related diseases, e.g., sarcopenia, cardiac aging, and Alzheimer's Disease. While longevity was consistently altered only by one transgenic and one knockout mouse model as predicted by the Oxidative Stress Theory of Aging, the incidence/progression of the three age-related diseases (especially Alzheimer's disease) were robustly impacted when the expression of various antioxidant genes was altered using transgenic and knockout mouse models.

Indexed as

AgingDisease Models, AnimalOxidative StressReactive Oxygen SpeciesAlzheimer DiseaseAnimalsAntioxidantsChronic DiseaseHumansLongevityMiceMice, KnockoutMice, TransgenicSarcopeniaAntioxidantsReactive Oxygen SpeciesAlzheimer's diseaseCardiac agingLifespanOxidative stressSarcopenia

Identifiers

PMID39419456
PMCPMC11624111

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.