Evidence map›Paper›PMID 39418796›Full record

ReviewCurrent opinion in structural biology2024

Extracellular DNA-protein interactions.

Steven D Goodman

Abstract readReview
In one paragraph

Review in Current opinion in structural biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Interaction BetweenMicroorganisms · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Steven D GoodmanAbigail Wexner Research Institute at Nationwide Children's Hospital, Center for Microbial Pathogenesis The Ohio State University College of Medicine 700 Children's Drive, WA5021 Columbus, OH 43205, USA. Electronic address: Steven.goodman@nationwidechildrens.org.

Funding

DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIAR01DC003915 · NIDCD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GOODMAN, STEVEN D · 1999 to 2025
$12.5M
HMGB1-mediated host response to chronic bacterial infectionR01AI155501 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GOODMAN, STEVEN D · 2020 to 2024
$3.6M
NIAID NIH HHS R01 AI155501NIDCD NIH HHS R01 DC003915
6 · The paper itself

Abstract

Intracellular DNA primarily serves as the cellular genetic material both in eukaryotes and prokaryotes. This function is often regulated by alterations in the DNA structure to accommodate transcription, recombination, and DNA replication. Extracellularly, both eukaryotic and prokaryotic cells take advantage of DNA plenty in addition to a permissive environment and create novel structures to fulfill multiple new roles. As often occurs intracellularly, extracellular DNA requires proteins to facilitate and stabilize these important structures. Here I review, both host and eubacterial nucleoprotein structures, their composition, their functions, and how these distinct structures can interact. Even at this early stage of study, it is clear that extracellular chromatin plays important biological roles in the survival of both prokaryotic and eukaryotic organisms.

Indexed as

DNAAnimalsDNA-Binding ProteinsExtracellular SpaceHumansNucleoproteinsProtein BindingDNADNA-Binding ProteinsNucleoproteins

Identifiers

PMID39418796
PMCPMC11703407

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.