Article in Journal of proteome research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Liqing HeDepartment of Chemistry, University of Louisville, Louisville, Kentucky 40208, United States.ORCID 0000-0002-0428-814X
Raobo XuDepartment of Chemistry, University of Louisville, Louisville, Kentucky 40208, United States.ORCID 0000-0002-7178-8961
Xipeng MaDepartment of Chemistry, University of Louisville, Louisville, Kentucky 40208, United States.
Xinmin YinDepartment of Chemistry, University of Louisville, Louisville, Kentucky 40208, United States.
Eugene MuellerDepartment of Chemistry, University of Louisville, Louisville, Kentucky 40208, United States.
Wenke FengUniversity of Louisville Alcohol Research Center, University of Louisville, Louisville, Kentucky 40208, United States.
Michael MenzeDepartment of Biology, University of Louisville, Louisville, Kentucky 40208, United States.ORCID 0000-0003-1072-5462
Seongho KimDepartment of Oncology, Wayne State University, Detroit, Michigan 48201, United States.
Craig J McClainUniversity of Louisville Alcohol Research Center, University of Louisville, Louisville, Kentucky 40208, United States.
Xiang ZhangDepartment of Chemistry, University of Louisville, Louisville, Kentucky 40208, United States.ORCID 0000-0003-1102-6313
Funding
Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI HOOD, JOSHUA L. · 2016 to 2025
$24.1M
The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN · 2016 to 2026
$17.9M
Integrated therapies for alcohol use and ALD (ITAALD) Network -UofL Clinical CenterU01AA026980 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN, Ashwani K Singal · 2018 to 2026
$2.9M
Intestine FXR activation by LGG-derived nanoparticles in alcohol-associated liver diseaseR01AA030424 · NIAAA · UNIVERSITY OF LOUISVILLE · PI WENKE FENG · 2022 to 2026
$2.6M
Ultra Performance Liquid Chromatography High Resolution High Mass Accuracy Mass SpectrometerS10OD020106 · OD · UNIVERSITY OF LOUISVILLE · PI ZHANG, XIANG · 2015 to 2015
$600k
RNA Modification Changes in Alcohol-Associated Liver DiseaseR21AA031563 · NIAAA · UNIVERSITY OF LOUISVILLE · PI HE, LIQING · 2024 to 2025
$400k
Pilot Trial UO1 DUR-928U01AA026934 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2018 to 2022
Metabolic dysfunction in the liver represents a predominant feature in the early stages of alcohol-associated liver disease (ALD). However, the mechanisms underlying this are only partially understood. To investigate the metabolic characteristics of the liver in ALD, we did a relative quantification of polar metabolites and lipids in the liver of mice with experimental ALD using untargeted metabolomics and untargeted lipidomics. A total of 99 polar metabolites had significant abundance alterations in the livers of alcohol-fed mice. Pathway analysis revealed that amino acid metabolism was the most affected by alcohol in the mouse liver. Metabolites involved in glycolysis and the TCA cycle were decreased, while glycerol 3-phosphate (G3P) and long-chain fatty acids were increased. Relative quantification of lipids unveiled an upregulation of multiple lipid classes, suggesting that alcohol consumption drives metabolism toward lipid synthesis. Results from enzyme expression and activity detection indicated that the decreased activity of mitochondrial glycerol 3-phosphate dehydrogenase contributed to the disordered metabolism.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Multiomics Studies on Metabolism Changes in Alcohol-Associated Liver Disease. · full record | OpenQuestion