Evidence map›Paper›PMID 39418342›Full record

ArticleScience (New York, N.Y.)2024

Reconstruction of the human amylase locus reveals ancient duplications seeding modern-day variation.

Feyza Yilmaz, Charikleia Karageorgiou, Kwondo Kim, Petar Pajic, Kendra Scheer, Human Genome Structural Variation Consortium, Christine R Beck, Ann-Marie Torregrossa, Charles Lee, Omer Gokcumen

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Ancient DNA and Human Physiology.Physiology (Bethesda, Md.) · 2026
    Review
  2. Article
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  4. High-coverage ancient genomes reveal divergent population histories and prehistoric starch-related genetic variation in Japan.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Feyza Yilmaz *The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID 0000-0001-8795-5800
Charikleia Karageorgiou *Department of Biological Sciences, University at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-6998-6926
Kwondo Kim *The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID 0000-0001-8254-528X
Petar PajicDepartment of Biological Sciences, University at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-6791-294X
Kendra ScheerDepartment of Biological Sciences, University at Buffalo, Buffalo, NY, USA.ORCID 0009-0008-0413-6307
Human Genome Structural Variation Consortium
Christine R BeckThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID 0000-0001-7821-8489
Ann-Marie TorregrossaDepartment of Psychology, University at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-9327-9885
Charles LeeThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID 0000-0001-7317-6662
Omer GokcumenDepartment of Biological Sciences, University at Buffalo, Buffalo, NY, USA.ORCID 0000-0003-4371-679X

Funding

Identifying and Characterizing the Full Spectrum of Haplotype-resolved Structural Variation in Human GenomesU24HG007497 · NHGRI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Evan Eichler, Jan Oliver Korbel · 2019 to 2026
$17.2M
Repetitive sequences drive genome variation and plasticityR35GM133600 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Christine R Beck · 2019 to 2026
$3.0M
NHGRI NIH HHS U24 HG007497NIGMS NIH HHS R35 GM133600
6 · The paper itself

Abstract

Previous studies suggested that the copy number of the human salivary amylase gene,

Indexed as

Evolution, MolecularGene DuplicationGenome, HumanHaplotypesSalivary alpha-AmylasesGene DosageHumansRecombination, GeneticSelection, GeneticStarchAMY1A protein, humanSalivary alpha-AmylasesStarch

Identifiers

PMID39418342
PMCPMC11707797

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.