Evidence map›Paper›PMID 39418305›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in

Shane K B Taylor, Jessica H Hartman, Bhagwati P Gupta

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Shane K B TaylorDepartment of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0003-4904-4314
Jessica H HartmanDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425.
Bhagwati P GuptaDepartment of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0001-8572-7054

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Exercise, MANF, and Chemical-Induced NeurodegenerationR00ES029552 · NIEHS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HARTMAN, JESSICA HELENE · 2021 to 2023
$751k
Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC) DiscoveryHHS | National Institutes of Health (NIH) R00-ES029552NIEHS NIH HHS R00 ES029552NIH HHS P40 OD010440
6 · The paper itself

Abstract

The conserved mesencephalic astrocyte-derived neurotrophic factor (MANF) is known for protecting dopaminergic neurons and functioning in various other tissues. Previously, we showed that

Indexed as

AutophagyCaenorhabditis elegansCaenorhabditis elegans ProteinsNerve Growth FactorsProteostasisAnimalsAnimals, Genetically ModifiedBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBasic Helix-Loop-Helix ProteinsEndoplasmic Reticulum StressLysosomesSignal TransductionBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBasic Helix-Loop-Helix ProteinsCaenorhabditis elegans ProteinsHLH-30 protein, C elegansmanf-1 protein, C elegansNerve Growth FactorsER stresslongevityMANF-1nematodeproteostasis

Identifiers

PMID39418305
PMCPMC11513987

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.