Evidence map›Paper›PMID 39418282›Full record

SynthesisEpigenetics2024

Epigenome-wide meta-analysis of prenatal vitamin D insufficiency and cord blood DNA methylation.

Elizabeth W Diemer, Johanna Tuhkanen, Sara Sammallahti, Kati Heinonen, Alexander Neumann, Sonia L Robinson, Matthew Suderman, Jianping Jin, Christian M Page, Ruby Fore and 17 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Elizabeth W DiemerDepartment of Child and Adolescent Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Johanna TuhkanenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Sara SammallahtiDepartment of Child and Adolescent Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Kati HeinonenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Alexander NeumannDepartment of Child and Adolescent Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Sonia L RobinsonEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Matthew SudermanMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Jianping JinWestat, Durham, NC, USA.
Christian M PageCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Ruby ForeDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Sheryl L Rifas-ShimanDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Emily OkenDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Patrice PerronFaculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC, Canada.
Luigi BouchardFaculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC, Canada.
Marie France HivertDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Katri RäikköneDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Jari LahtiDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Edwina H YeungEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Weihua GuanDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Sunni L MumfordEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Maria C MagnusCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Siri HåbergCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Wenche NystadDepartment of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway.
Christine L ParrDepartment of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway.
Stephanie J LondonDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Janine F FelixGeneration R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Henning TiemeierDepartment of Child and Adolescent Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI A. Clementina Mesaros · 2006 to 2026
$35.3M
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Epigenetic Pathways to Conduct Problem Trajectories: Early Environmental RisksR01HD068437 · NICHD · KING'S COLLEGE LONDON · PI BARKER, EDWARD D., MILL, JONATHAN · 2012 to 2014
$1.1M
Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009NICHD NIH HHS R01 HD034568NICHD NIH HHS R01 HD068437NIEHS NIH HHS P30 ES013508Wellcome Trust
6 · The paper itself

Abstract

Low maternal vitamin D concentrations during pregnancy have been associated with a range of offspring health outcomes. DNA methylation is one mechanism by which the maternal vitamin D status during pregnancy could impact offspring's health in later life. We aimed to evaluate whether maternal vitamin D insufficiency during pregnancy was conditionally associated with DNA methylation in the offspring cord blood. Maternal vitamin D insufficiency (plasma 25-hydroxy vitamin D

Indexed as

DNA MethylationEpigenomeFetal BloodVitamin D DeficiencyEpigenesis, GeneticFemaleGenome-Wide Association StudyHumansMalePregnancyPrenatal Exposure Delayed EffectsVitamin DVitamin DDNA methylationepigeneticsEWASPACEpregnancyVitamin DVitamin D insufficiency

Identifiers

PMID39418282
PMCPMC11487971

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.