ArticleQJM : monthly journal of the Association of Physicians2025
Pre-emptive pharmacogenetic testing in the acute hospital setting: a cross-sectional study.
Article in QJM : monthly journal of the Association of Physicians, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Implementation of a Pharmacogenomic Service in a Pediatric Community Hospital.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
- Bridging the Gap Between Pharmacogenomic Discovery and Clinical Implementation: Insights from Selected Studies on Inter-Individual Variability in Drug Response.Journal of personalized medicine · 2026Article
- Pharmacogenetic Implementation Studies-Lessons Learned From the PREPARE Study.Clinical pharmacology and therapeutics · 2025Article
- Embedding Pharmacogenetics Into Clinical Practice to Improve Patient Outcomes.Annals of human genetics · 2025Review
- Pharmacogenomics to Improve Supportive Care Symptoms. A Prospective Observational Study Protocol.NIHR open research · 2025Article
- Pharmacogenetic analyses in people with dementia in Northeast Germany.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Review
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
backgroundPharmacogenetic-guided prescribing can be used to improve the safety and effectiveness of medicines. There are several approaches by which this intervention might be implemented in clinical practice, which will vary depending on the health system and clinical context.
aimTo understand the clinical utility of panel-based pharmacogenetic testing in patients admitted acutely to hospital and to establish variables that predict if an individual might benefit from the intervention.
designA cross-sectional study recruiting patients admitted acutely to hospital.
methodsParticipants underwent panel-based pharmacogenetic testing, and their genetic results were analysed in their context of the medicines they had been exposed to as an inpatient. The primary outcome was the proportion of patients with clinically actionable gene-drug interactions. Individual variables that predict the clinical utility of pharmacogenetic testing were established via logistic regression.
resultsGenetic and prescribing data were available for 482 inpatients (55% male; median age 61.2 years; range: 18-96), 97.9% of whom carried a pharmacogenetic result of interest. During their admission, 79.5% of patients were exposed to a medicine for which there is pharmacogenetic prescribing guidance available. Just under one in seven individuals (13.7%) had a clinically actionable gene-drug interaction. Increasing age (>50 years) was positively correlated with the likelihood (2.7-fold increased risk) of having a clinically actionable interaction.
conclusionsThese findings demonstrate the potential scale, and potential clinical utility, of pharmacogenetic testing as an intervention, highlighting the need to develop infrastructure to support healthcare professionals make use of this emerging tool.
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