Evidence map›Paper›PMID 39418098›Full record

ReviewAging2024

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.

Yu-Xuan Lyu, Qiang Fu, Dominika Wilczok, Kejun Ying, Aaron King, Adam Antebi, Aleksandar Vojta, Alexandra Stolzing, Alexey Moskalev, Anastasia Georgievskaya and 116 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Review
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  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. The Morphological, Behavioral, and Transcriptomic Life Cycle of Anthrobots.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  15. Aging · 2025
    Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

126 authors.

Yu-Xuan LyuInstitute of Advanced Biotechnology and School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Qiang FuInstitute of Aging Medicine, College of Pharmacy, Binzhou Medical University, Yantai, China.
Dominika WilczokDuke Kunshan University, Kunshan, Jiangsu, China.
Kejun YingDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02108, USA.
Aaron KingForesight Institute, San Francisco, CA 91125, USA.
Adam AntebiMax Planck Institute for Biology of Ageing, Cologne, Germany.
Aleksandar VojtaDepartment of Biology, Division of Molecular Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia.
Alexandra StolzingCentre for Biological Engineering, Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK.
Alexey MoskalevInstitute of Biogerontology, Lobachevsky University, Nizhny Novgorod, Russia.
Anastasia GeorgievskayaHautAI OÜ, Tallinn, Estonia.
Andrea B MaierHealthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Andrea OlsenCalifornia Institute of Technology, Pasadena, CA 91125, USA.
Anja GrothNovo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Anna Katharina SimonMax Delbrück Center for Molecular Medicine, Berlin, Germany.
Anne BrunetDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.
Aisyah JamilInsilico Medicine AI Limited, Level 6, Masdar City, Abu Dhabi, UAE.
Anton KulagaSystems Biology of Aging Group, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania.
Asif BhattiAmerica's Frontier Fund, VA 23320, USA.
Benjamin YadenDepartment of Biology, School of Science, Center for Developmental and Regenerative Biology, Indiana University - Purdue University Indianapolis, Indianapolis Indiana 46077, USA.
Bente Klarlund PedersenCentre for Physical Activity Research, Rigshospitalet and University of Copenhagen, Denmark.
Björn SchumacherInstitute for Genome Stability in Aging and Disease, CECAD Research Center, University and University Hospital of Cologne, Cologne 50931, Germany.
Boris Djordjevic199 Biotechnologies Ltd., London, UK.
Brian KennedyHealthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Chieh ChenMolecular, Cellular, And Integrative Physiology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA 90095, USA.
Christine Yuan HuangHong Kong Quantum AI Lab, Hong Kong.
Christoph U CorrellZucker School of Medicine at Hofstra/Northwell, NY 10001, USA.
Coleen T MurphyLewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA.
Collin Y EwaldLaboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, Schwerzenbach CH-8603, Switzerland.
Danica ChenDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Dario Riccardo ValenzanoLeibniz Institute on Aging, Fritz Lipmann Institute, Friedrich Schiller University, Jena, Germany.
Dariusz SołdackiLongevity Center Europe, Warsaw, Poland.
David ErritzoeCentre for Psychedelic Research, Dpt Brain Sciences, Imperial College London, UK.
David MeyerInstitute for Genome Stability in Aging and Disease, CECAD Research Center, University and University Hospital of Cologne, Cologne 50931, Germany.
David A SinclairBlavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA 02108, USA.
Eduardo Nunes ChiniSignal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, MN 55902, USA.
Emma C TeelingSchool of Biology and Environmental Science, Belfield, Univeristy College Dublin, Dublin 4, Ireland.
Eric MorgenBioAge Labs, Richmond, CA 94530, USA.
Eric VerdinBuck Institute for Research on Aging, Novato, CA 94945, USA.
Erik VernetResearch and Early Development, Maaleov 2760, Denmark.
Estefano PinillaVitaDAO, Ottawa, ON K1V 9K6, Canada.
Evandro F FangDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Evelyne BischofDepartment of Medical Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Evi M MerckenNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen 2200, Denmark.
Fabian FingerNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen N 2200, Denmark.
Folkert KuipersEuropean Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Frank W PunInsilico Medicine Hong Kong Ltd., Hong Kong Science and Technology Park, Hong Kong SAR, China.
Gabor GyülvesziRejuveron Life Sciences AG, 8952 Schlieren, Switzerland.
Gabriele CivilettoHealth, Nutrition and Care, DSM-Firmenich, Kaiseraugst, Switzerland.
Garri ZmudzeLongeVC, Riga, Latvia.
Gil BlanderInsideTracker, Cambridge, MA 02114, USA.
Harold A PincusDepartment of Psychiatry, Columbia University, New York, NY 10012, USA.
Joshua McClureMaxwell Biosciences, Austin, TX 73301, USA.
James L KirklandDivision of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
James PeyerCambrian Bio, Inc., New York, NY 10012, USA.
Jamie N JusticeXPRIZE Foundation, Culver City, CA 90230, USA.
Jan VijgDepartment of Genetics Albert Einstein College of Medicine, New York, NY 10461, USA.
Jennifer R GruhnDepartment of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jerry McLaughlinLife Biosciences, Boston, MA 02116, USA.
Joan MannickTornado Therapeutics, Cambrian Bio Inc. PipeCo, New York, NY 10012, USA.
João PassosDepartment of Physiology and Biomedical Engineering and Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Joseph A BaurDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19019, USA.
Joe Betts-LaCroixRetro Biosciences, Inc., Redwood City, CA 94061, USA.
John M SedivyCenter on the Biology of Aging, Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02860, USA.
John R SpeakmanShenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Jordan ShlainPrivate Medical, San Francisco, CA 94107, USA.
Julia von MaltzahnFaculty of Health Sciences Brandenburg and Faculty of Environment and Natural Sciences, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg 01968, Germany.
Katrin I AndreassonDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kelsey MoodyIchor Life Sciences, Inc., LaFayette, NY 13084, USA.
Konstantinos PalikarasDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Kristen FortneyBioAge Labs, Richmond, CA 94530, USA.
Laura J NiedernhoferInstitute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55414, USA.
Lene Juel RasmussenCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.
Liesbeth M VeenhoffEuropean Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Lisa MeltonNature Biotechnology, Springer Nature, London, UK.
Luigi FerrucciLongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21201, USA.
Marco QuartaRubedo Life Sciences, Sunnyvale, CA 94043, USA.
Maria KovalInstitute of Biochemistry of the Romanian Academy, Romania.
Maria MarinovaFertility and Research Centre, Discipline of Women's Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Mark HamalainenLongevity Biotech Fellowship, Longevity Acceleration Fund, Vitalism, SF Bay, CA 94101, USA.
Maximilian UnfriedHealthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Michael S RingelBoston Consulting Group, Boston, MA 02210, USA.
Milos FilipovicLeibniz-Institut Für Analytische Wissenschaften-ISAS-E.V., Dortmund, Germany.
Mourad ToporsRepair Biotechnologies, Inc., Syracuse, NY 13210, USA.
Natalia MitinSapere Bio, Triangle Research Park, NC 27213, USA.
Nawal RoyHolmusk, New York, NY 10012, USA.
Nika PintarAniBiome, Zagreb, Croatia.
Nir BarzilaiInstitute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10452, USA.
Paolo BinettiVitaDAO, Ottawa, ON K1V 9K6, Canada.
Parminder SinghBuck Institute for Research on Aging, Novato, CA 94945, USA.
Paul KohlhaasMolecule, Neuhausen am Rheinfall, Switzerland.
Paul D RobbinsInstitute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology, and Biochemistry, University of Minnesota, Minneapolis, MN 55111, USA.
Paul RubinBioAge Labs, Richmond, CA 94530, USA.
Peter O FedichevGero PTE, Singapore, Singapore.
Petrina KamyaInsilico Medicine Canada Inc., Montreal, Quebec H3B 4W8 Canada.
Pura Muñoz-CanovesAltos Labs Inc., San Diego Institute of Science, San Diego, CA 92121, USA.
Rafael de CaboTranslational Gerontology Branch, Intramural Research Program, National Institute on Aging (NIH), Baltimore, Maryland 21201, USA.
Richard G A FaragherHuxley Building, School of Applied Sciences, University of Brighton, Brighton, UK.
Rob KonradBiolytica, Zug, Switzerland.
Roberto RipaMax Planck Institute for Biology of Ageing, Cologne, Germany.
Robin MansukhaniDeciduous Therapeutics, San Francisco, CA 94107, USA.
Sabrina BüttnerDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm 10691, Sweden.
Sara A WickströmDepartment of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
Sebastian BrunemeierHealthspan Capital, El Cerrito, CA 94530, USA.
Sergey JakimovLongeVC, Riga, Latvia.
Shan LuoSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Sharon Rosenzweig-LipsonLife Biosciences, Boston, MA 02116, USA.
Shih-Yin TsaiDepartment of Physiology, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Stefanie DimmelerInstitute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Germany.
Thomas A RandoEli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095, USA.
Tim R PetersonBioio, Inc., St. Louis, MO 63110, USA.
Tina WoodsCollider Heath, London, UK.
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Toren FinkelAging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15106, USA.
Tzipora StraussSheba Longevity Center, Sheba Medical Center, Tel Hashomer, Israel.
Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02108, USA.
Valter D LongoLongevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90001, USA.
Varun B DwarakaTruDiagnostic, Lexington, KY 40503, USA.
Vera GorbunovaDepartment of Biology and Medicine, University of Rochester, Rochester, NY 14627, USA.
Victoria A Acosta-RodríguezDepartment of Neuroscience, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Vincenzo SorrentinoHealthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Vittorio SebastianoDepartment of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA 94301, USA.
Wenbin LiDepartment of Neuro-Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Yousin SuhDepartment of Obstetrics and Gynecology, Columbia University, New York City, NY 10032, USA.
Alex ZhavoronkovInsilico Medicine AI Limited, Level 6, Masdar City, Abu Dhabi, UAE.
Morten Scheibye-KnudsenCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.
Daniela BakulaCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
THE IMPACT OF CELLULAR DEFENSE ON THE ROLE OF Ku80 IN GENOME MAINTENANCE AND LONGP01AG017242 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI VIJG, JAN · 1999 to 2023
$46.1M
The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI Vadim N. Gladyshev · 2014 to 2026
$36.9M
Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, Nathan K LeBrasseur · 2019 to 2026
$28.7M
Validation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI NIR J BARZILAI, Paul D. Robbins · 2017 to 2026
$24.5M
Midwest Murine-Tissue Mapping Center (MM-TMC)U54AG079754 · NIA · UNIVERSITY OF MINNESOTA · PI GR Scott Budinger, Sundeep Khosla · 2022 to 2026
$11.5M
Minnesota Tissue Mapping Center for Senescent CellsU54AG076041 · NIA · UNIVERSITY OF MINNESOTA · PI Constantin F. Aliferis, LAURA Jane NIEDERNHOFER · 2021 to 2026
$10.5M
Effect of Aging on Preadipocyte DifferentiationR37AG013925 · NIA · MAYO CLINIC ROCHESTER · PI KIRKLAND, JAMES L. · 2016 to 2025
$6.6M
Translational Geroscience NetworkR33AG061456 · NIA · MAYO CLINIC ROCHESTER · PI JAMES L. KIRKLAND, STEPHEN B. KRITCHEVSKY · 2019 to 2026
$6.2M
The role of SIRT6 posttranslational modifications in aging and genome stability. Supplement: Testing SIRT6 activators as potential Alzheimer's disease therapy.R01AG027237 · NIA · UNIVERSITY OF ROCHESTER · PI Vera Gorbunova · 2006 to 2026
$6.2M
Enhancer-based Immune and Beta Cell Dysregulation Underlying T1D RiskR01DK127778 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EGLI, DIETER MEINRAD, ROSENFELD, MICHAEL G · 2020 to 2023
$4.5M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NCI NIH HHS UG3 CA268103NEI NIH HHS R43 EY034403NHLBI NIH HHS U01 HL145560NIA NIH HHS P01 AG017242NIA NIH HHS P01 AG047200NIA NIH HHS P01 AG062413NIA NIH HHS R01 AG027237NIA NIH HHS R01 AG063389NIA NIH HHS R01 AG063404NIA NIH HHS R01 AG063543NIA NIH HHS R01 AG068048NIA NIH HHS R01 AG068667NIA NIH HHS R01 AG082105NIA NIH HHS R01 AG082708NIA NIH HHS R01 AG082764NIA NIH HHS R33 AG061456NIA NIH HHS R37 AG013925NIA NIH HHS U19 AG056278NIA NIH HHS U54 AG076041NIA NIH HHS U54 AG079754NIDDK NIH HHS R01 DK117481NIDDK NIH HHS R01 DK127778NIEHS NIH HHS U01 ES029519Wellcome Trust
6 · The paper itself

Abstract

The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

Indexed as

Artificial IntelligenceBiomarkersBiotechnologyLongevityAgingGeroscienceHumansBiomarkersartificial intelligencebiotechnologyhealthy longevity

Identifiers

PMID39418098
PMCPMC11552646

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.