Evidence map›Paper›PMID 39417943›Full record

SynthesisInternational journal of clinical oncology2024

Efficacy and safety of dexamethasone sparing for the prevention of nausea and vomiting associated with moderately emetogenic chemotherapy: a systematic review and meta-analysis of Clinical Practice Guidelines for Antiemesis 2023 from Japan Society of Clinical Oncology.

Kazuhisa Nakashima, Ayako Yokomizo, Michiyasu Murakami, Kenji Okita, Makoto Wada, Keiko Iino, Tatsuo Akechi, Hirotoshi Iihara, Chiyo K Imamura, Ayako Okuyama and 18 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in International journal of clinical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Kazuhisa NakashimaDepartment of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, Shimane, 693-8501, Japan.
Ayako YokomizoDepartment of Early Clinical Development, Kyoto University Graduate School of Medicine, Kyoto University Hospital, 54 Kawahara-Cho, Shogoin, Sakyo-Ku, Kyoto, 606-8507, Japan. ayokomizo@kuhp.kyoto-u.ac.jp.
Michiyasu MurakamiDepartment of Pharmacy, Matsuyama Red Cross Hospital, 1 Bunkyo-Cho, Matsuyama-Shi, Ehime, 790-8524, Japan.
Kenji OkitaDepartment of Surgery, Otaru Ekisaikai Hospital, 1-4‑1, Inaho, Otaru, Hokkaido, 047‑0032, Japan.
Makoto WadaDepartment of Psycho-Oncology, Osaka International Cancer Institute, 3-1‑69, Chuo-Ku, Osaka, 541‑8567, Japan.
Keiko IinoSchool of Nursing, National College of Nursing, 1-2‑1, Umezono, Kiyose, Tokyo, 204‑8575, Japan.
Tatsuo AkechiDepartment of Psychiatry and Cognitive‑Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho‑Cho, Mizuho-Ku, Nagoya, 467-8601, Japan.
Hirotoshi IiharaDepartment of Pharmacy, Gifu University Hospital, 1-1 Yanagido, Gifu, Gifu, 501‑1194, Japan.
Chiyo K ImamuraAdvanced Cancer Translational Research Institute, Showa University, 1‑5‑8 Hatanodai, Shinagawa‑Ku, Tokyo, 142‑8555, Japan.
Ayako OkuyamaGraduate School of Nursing Science, St. Luke's International University, 10-1 Akashi-Cho, Chuo-Ku, Tokyo, 104‑0044, Japan.
Keiko OzawaDivision of Survivorship Institute for Cancer Control, National Cancer Center, 5‑1‑1 Tsukiji, Chuo-Ku, Tokyo, 104‑0045, Japan.
Yong-Il KimDivision of Medical Oncology, Yodogawa Christian Hospital, 1‑7‑50 Kunijima, Higasiyodogawa-Ku, Osaka, Osaka, 533‑0024, Japan.
Hidenori SasakiDivision of Medical Oncology, Hematology and Infectious Disease, Fukuoka University Hospital, 7-45‑1, Nanakuma, Jonan‑Ku, Fukuoka, 814‑0180, Japan.
Eriko SatomiDepartment of Palliative Medicine, National Cancer Center Hospital, 5‑1‑1 Tsukiji , Chuo-ku, Tokyo, 104‑0045, Japan.
Masayuki TakedaDepartment of Cancer Genomics and Medical Oncology, Nara Medical University, 840 Shijo-Cho, Kashihara, Nara, 634‑8521, Japan.
Ryuhei TanakaDepartment of Pediatric Hematology/Oncology, International Medical Center, Saitama Medical University, 1398-1 Yamane, Hidaka, Saitama, 350‑1298, Japan.
Takako Eguchi NakajimaDepartment of Early Clinical Development, Kyoto University Graduate School of Medicine, Kyoto University Hospital, 54 Kawahara-Cho, Shogoin, Sakyo-Ku, Kyoto, 606-8507, Japan.
Naoki NakamuraDepartment of Radiation Oncology, St. Marianna University, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan.
Junichi NishimuraDepartment of Gastroenterological Surgery, Osaka International Cancer Institute, 3-1‑69, Osaka, 541‑8567, Japan.
Mayumi NodaNon-Profit Organization Sasaeau-Kai "Alpha", 518-7 Kawado-Cho, Chuo-Ku, Chiba, Chiba, 260‑0802, Japan.
Kazumi HayashiDepartment of Clinical Oncology and Hematology, The Jikei University School of Medicine, 3‑25‑8 Nishi‑Shinnbashi Minatoku, Tokyo, 105‑8461, Japan.
Takahiro HigashiDepartment of Public Health and Health Policy, The University of Tokyo, 7‑3‑1 Hongo, Bunkyo‑Ku, Tokyo, 113‑0033, Japan.
Narikazu BokuDepartment of Oncology and General Medicine, IMSUT Hospital, Institute of Medical Science, University of Tokyo, 4‑6‑1 Shiroganedai, Minato-Ku, Tokyo, 108‑8639, Japan.
Koji MatsumotoDivision of Medical Oncology, Hyogo Cancer Center, 13-70 Kitaoji-Cho, Akashi, Hyogo, 673‑0021, Japan.
Yoko MatsumotoNon-Profit Organization Ehime Cancer Support Orange-No-Kai, 3‑8‑24 Furukawaminami, Matsuyama, Ehime, 790‑0943, Japan.
Nobuyuki YamamotoInternal Medicine III, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama, 641‑8509, Japan.
Kenjiro AogiDepartment of Breast Surgery, National Hospital Organization Shikoku Cancer Center, 160 Kou, Minamiumemoto-Machi, Matsuyama, Ehime, 791‑0280, Japan.
Masakazu AbeDepartment of Obstetrics and Gynecology, Hamamatsu University School of Medicine, 1‑20‑1 Handayama, Chuo-Ku, Hamamatsu, Shizuoka, 431‑3192, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPalonosetron, a second-generation 5-HT

methodsThe PubMed, Cochrane Library, and Ichushi-Web databases were searched for relevant studies published between 1990 and 2020. We included studies that compared the efficacy of 1- and 3-day DEX administration in preventing nausea and vomiting associated with MEC. Outcomes were "prevention of vomiting (complete response rate and no vomiting rate)," "prevention of nausea" (complete control rate, total control rate, no nausea rate, and no clinically significant nausea rate)" in the delayed phase, "prevention of blood glucose level elevation," and "prevention of osteoporosis."

resultsEight studies were included in this systematic review. The no vomiting rate was significantly higher in the 3-day DEX group than in the 1-day DEX group. However, the other efficacy items did not significantly differ between the two groups. Meanwhile, insufficient evidence was obtained for "prevention of blood glucose level elevation" and "prevention of osteoporosis."

conclusionsNo significant differences in most antiemetic effects were found between 1- and 3-day DEX administration. Thus, DEX administration could be shortened from 3 days to 1 day when used in combination with palonosetron.

Indexed as

AntiemeticsDexamethasoneNauseaPalonosetronVomitingAntineoplastic AgentsHumansJapanNeoplasmsPractice Guidelines as TopicSerotonin 5-HT3 Receptor AntagonistsAntiemeticsAntineoplastic AgentsDexamethasonePalonosetronSerotonin 5-HT3 Receptor AntagonistsChemotherapy-induced nausea and vomitingDexamethasoneMeta-analysisModerately emetogenic chemotherapyPalonosetronSystematic review

Identifiers

PMID39417943

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.