Evidence map›Paper›PMID 39417933›Full record

ReviewNano-micro letters2024

Unleashing the Potential of Electroactive Hybrid Biomaterials and Self-Powered Systems for Bone Therapeutics.

Shichang Liu, Farid Manshaii, Jinmiao Chen, Xinfei Wang, Shaolei Wang, Junyi Yin, Ming Yang, Xuxu Chen, Xinhua Yin, Yunlei Zhou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nano-micro letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Review
  3. Topologically Structured PLLA Fibers With Stress Concentration Effects for Health Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Biodegradable MgBioactive materials · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shichang LiuHonghui Hospital, Xi'an Jiaotong University, Xi'an, 710018, People's Republic of China.
Farid ManshaiiDepartment of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California Los Angeles, Los Angeles, 90095, USA.
Jinmiao ChenHangzhou Institute of Technology, Xidian University, Hangzhou, 311231, People's Republic of China.
Xinfei WangDepartment of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California Los Angeles, Los Angeles, 90095, USA.
Shaolei WangDepartment of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California Los Angeles, Los Angeles, 90095, USA.
Junyi YinDepartment of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California Los Angeles, Los Angeles, 90095, USA.
Ming YangHonghui Hospital, Xi'an Jiaotong University, Xi'an, 710018, People's Republic of China. spine_ym@163.com.
Xuxu ChenHonghui Hospital, Xi'an Jiaotong University, Xi'an, 710018, People's Republic of China. firrain@126.com.
Xinhua YinHonghui Hospital, Xi'an Jiaotong University, Xi'an, 710018, People's Republic of China. YIN700@outlook.com.
Yunlei ZhouHangzhou Institute of Technology, Xidian University, Hangzhou, 311231, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of large bone defects caused by traumatic injury is increasing worldwide, and the tissue regeneration process requires a long recovery time due to limited self-healing capability. Endogenous bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and regeneration. Inspired by bioelectricity, electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix, thereby accelerating bone regeneration. With ongoing advances in biomaterials and energy-harvesting techniques, electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone tissue. In this review, we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and tissue. Next, we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue engineering. Finally, we emphasize the significance of simulating the target tissue's electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

Indexed as

Bone regenerationBone tissueElectroactive biomaterialsSelf-powered bioelectronics

Identifiers

PMID39417933
PMCPMC11486894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.