Evidence map›Paper›PMID 39417784›Full record

ArticleChemMedChem2025

Synthesis, Characterization, and Biological Activity of New 4'-Functionalized Bis-Terpyridine Ruthenium(II) Complexes: Anti-Inflammatory Activity Advances.

Mohamed M Elnagar, Khaled S Abou-El-Sherbini, Safia Samir, Walid Sharmoukh, Mohamed S Abdel-Aziz, Yasser M Shaker

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In one paragraph

Article in ChemMedChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohamed M ElnagarInstitute of Electrochemistry, Ulm University, Albert-Einstein-Allee 47, 89081, Ulm, Germany.ORCID https://orcid.org/0000-0003-4315-3878
Khaled S Abou-El-SherbiniDepartment of Inorganic Chemistry, National Research Centre, 33 El Bohouth St. (former Tahrir St.), 12622, Dokki, Giza, Egypt.
Safia SamirDepartment of Biochemistry and Molecular Biology, Theodor Bilharz Research Institute, P.O. Box 30, Giza, Egypt.
Walid SharmoukhDepartment of Inorganic Chemistry, National Research Centre, 33 El Bohouth St. (former Tahrir St.), 12622, Dokki, Giza, Egypt.
Mohamed S Abdel-AzizDepartment of Microbial Chemistry, National Research Centre, 33 El Bohouth St. (former Tahrir St.), 12622, Dokki, Giza, Egypt.
Yasser M ShakerDivision of Pharmaceutical and Drug Industries, Department of the Chemistry of Natural and Microbial Products, National Research Centre, El Buhouth Street, Dokki, Cairo, 12622, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ruthenium complexes incorporating 2,2' : 6',2''-terpyridine ligands have emerged as promising candidates due to their versatile biological activities including DNA-binding, anti-inflammatory, antimicrobial, and anticancer properties. In this study, three new 4'-functionalized bis(terpyridine) Ru(II) complexes were synthesized. These complexes feature one ligand as 4-(2,2' : 6',2''-terpyridine-4'-yl) benzoic acid and the second ligand as either 4'-(2-thienyl)-2,2' : 6',2''-terpyridine, 4'-(3,4-dimethoxyphenyl)-2,2' : 6',2''-terpyridine, or 4'-(4-dimethylaminophenyl)-2,2' : 6',2''-terpyridine. Besides the chemical characterization by

Indexed as

Anti-Bacterial AgentsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalCoordination ComplexesPyridinesRutheniumAnimalsAntineoplastic AgentsCell SurvivalDose-Response Relationship, DrugHumansLipopolysaccharidesMiceMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsCoordination ComplexesLipopolysaccharidesPyridinesRutheniumAnti-cancerAnti-inflammatoryAntimicrobial agentsBiological activityRu(II) complexesTerpyridine

Identifiers

PMID39417784
PMCPMC11793853

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.