ReviewImmunity, inflammation and disease2024
Interactions between sleep, inflammation, immunity and infections: A narrative review.
Review in Immunity, inflammation and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Inflammatory exposures in early pregnancy and multidimensional sleep in late pregnancy: a prospective population-based study.Brain, behavior, & immunity - health · 2026Article
- 'Teleonomes in Tatters': The Welfare Costs of Selecting Dogs for Extreme Phenotypes, and the Case for Change.Animals : an open access journal from MDPI · 2026Article
- Toward a Unified Neuroimmune Framework for Infection-Associated Psychiatric Disorders.Diseases (Basel, Switzerland) · 2026Review
- Chronic Sleep Disturbance Enhances Inflammation and Collagen Production in Neural- and Myofascial Tissues in Uninjured Rats.International journal of molecular sciences · 2026Article
- Psychological consequences of insufficient sleep in medical students.Discover mental health · 2026Article
- Sleep and Cytokines: A Bidirectional Dialogue Involving Rest and Immunity.Children (Basel, Switzerland) · 2026Review
- The Microbiota-Gut-Brain Axis in Insomnia: Mechanisms and Intervention Strategies.Life (Basel, Switzerland) · 2026Review
- Silent Nights, Restless Lungs: Sleep Quality and Associated Factors Among COPD Patients in Vietnam - A Cross-Sectional Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026Article
- Association between high-density lipoprotein-related inflammation index and prevalence of sleep disorders with depression as a mediator.European archives of psychiatry and clinical neuroscience · 2026Article
- Association between urinary polycyclic aromatic hydrocarbon metabolites and sleep disturbances: A cross-sectional study integrating machine learning and network toxicology.The Journal of international medical research · 2026Article
- The Differential Associations Between Passive and Interactive Screentime and Sleep Duration Among 8th and 11th Grade Adolescents.Children (Basel, Switzerland) · 2026Article
- Altered neurovascular coupling and associated neurotransmitter profiles in inflammatory bowel disease with distinct depressive symptoms.Journal of neuroinflammation · 2026Article
- Evidence-based sleep promotion in acute care from the perspective of nursing staff: a cross-sectional study.BMC nursing · 2026Article
- Circadian-immune crosstalk in insomnia disorder: mechanisms and therapeutic implications.Frontiers in neuroscience · 2026Review
- Socioeconomic disparities and life's essential 8: a focused review and considerations for improving cardiovascular health in the United States.Frontiers in cardiovascular medicine · 2026Article
- Cloning of a novel cyanobacterial serotonin N-acetyltransferase gene CySNAT3 and its integration with transcriptomic drug repurposing in pediatric obstructive sleep-disordered breathing.Frontiers in pharmacology · 2026Article
- Inflammatory Proteins Mediate the Causal Association between Sleep Traits and Breast Cancer: A Mendelian Randomization Study.Lifestyle genomics · 2026Article
- Interpretable Machine Learning for Predicting Cefoperazone-Sulbactam-Associated Coagulation Abnormalities in Elderly Inpatients: A Dual-Center Retrospective Study.Diagnostics (Basel, Switzerland) · 2025Article
- Review
- The Impact of Insomnia on the Clinical Course and Treatment Outcomes of Rheumatoid Arthritis.Biomedicines · 2025Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOver the past decades, it has become increasingly evident that sleep disturbance contributes to inflammation-mediated disease, including depression, mainly through activation of the innate immune system and to an increased risk of infections.
methodsA comprehensive literature search was performed in PubMed to identify relevant research findings in the field of immunity, inflammation and infections, with a focus on translational research findings from the past 5 years.
resultsPhysiological sleep is characterized by a dynamic interplay between the immune system and sleep architecture, marked by increased innate immunity and T helper 1 (Th1) -mediated inflammation in the early phase, transitioning to a T helper 2 (Th2) response dominating in late sleep. Chronic sleep disturbances are associated with enhanced inflammation and an elevated risk of infections, while other inflammatory diseases may also be affected. Conversely, inflammation in response to infection can also disrupt sleep patterns and architecture. This narrative review summarizes current data on the complex relationships between sleep, immunity, inflammation and infections, while highlighting translational aspects. The bidirectional nature of these interactions are addressed within specific conditions such as sleep apnea, HIV, and other infections. Furthermore, technical developments with the potential to accelerate our understanding of these interactions are identified, including advances in wearable devices, artificial intelligence, and omics technology. By integrating these tools, novel biomarkers and therapeutic targets for sleep-related immune dysregulation may be identified.
conclusionThe review underscores the importance of understanding and addressing immune imbalance related to sleep disturbances to improve disease outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.