Evidence map›Paper›PMID 39417611›Full record

ArticleInternational journal of cancer2025

Ninjurin1 deficiency differentially mitigates colorectal cancer induced by azoxymethane and dextran sulfate sodium in male and female mice.

Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Jae Young Jang, Eun Hye Kim, Sungchan Ha, Eun Shin, Hoon Choi, Kyu-Won Kim and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. The role of NINJ1 in diseases.Cell death discovery · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chin-Hee SongDepartment of Internal Medicine and Research Center for Sex- and Gender-Specific Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea.
Nayoung KimDepartment of Internal Medicine and Research Center for Sex- and Gender-Specific Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea.ORCID 0000-0002-9397-0406
Ryoung Hee NamDepartment of Internal Medicine and Research Center for Sex- and Gender-Specific Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea.
Soo In ChoiDepartment of Internal Medicine and Research Center for Sex- and Gender-Specific Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea.
Jae Young JangDepartment of Internal Medicine and Research Center for Sex- and Gender-Specific Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea.
Eun Hye KimDepartment of Internal Medicine and Research Center for Sex- and Gender-Specific Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea.
Sungchan HaDepartment of Internal Medicine and Research Center for Sex- and Gender-Specific Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea.
Eun ShinDepartment of Pathology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Gyeonggi-do, South Korea.
Hoon ChoiCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, South Korea.
Kyu-Won KimCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, South Korea.
Sejin JeonDepartment of Vaccine Biothechnology, Andong National University, Andong, South Korea.
Goo Taeg OhDepartment of Life Sciences, Heart-Immune-Brain Network Research Center, Ewha Womans University, Seoul, South Korea.
Yeong-Jae SeokDepartment of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul, South Korea.

Funding

National Research Foundation of Korea 2019R1A2C2085149Seoul National University Bundang Hospital 02-2020-041Seoul National University Bundang Hospital 06-2021-0018
6 · The paper itself

Abstract

This study investigated the role of Ninjurin1 (Ninj1), encoding a small transmembrane protein, in colitis-associated colon tumorigenesis in relation to sex hormones. Male and female wild-type (WT) and Ninj1 knockout (KO) mice were treated with azoxymethane (AOM) and dextran sulfate sodium (DSS), with or without testosterone propionate (TP). At week 2 (acute colitis stage), Ninj1 KO exhibited an alleviation in the colitis symptoms in both male and female mice. The M2 macrophage population increased and CD8

Indexed as

AzoxymethaneCell Adhesion Molecules, NeuronalColorectal NeoplasmsDextran SulfateMacrophagesMice, KnockoutAnimalsCD8-Positive T-LymphocytesColitisFemaleMaleMiceMice, Inbred C57BLNerve Growth FactorsSex FactorsTestosteroneAzoxymethaneCell Adhesion Molecules, NeuronalDextran SulfateNerve Growth FactorsNinj1 protein, mouseTestosteronecolitis‐associated neoplasmsNINJ1 proteinsex characteristicstestosterone propionate

Identifiers

PMID39417611
PMCPMC11661511

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.