ArticleJournal of primary care & community health
Patient Perceived Barriers and Enablers to Medication Adherence in the Treatment of Depression: A Qualitative Study.
Article in Journal of primary care & community health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Primary care physicians' knowledge, attitudes, and clinical practices regarding the management of anxiety and depressive disorders in Georgia.Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi · 2026Article
- Investigating the Use of Antidepressants in Treating Major Depressive Disorder:Saudi medical journal · 2026Article
- Understanding Adherence to Duloxetine in Psychiatric Practice: A Cross-Sectional Evaluation of Clinicians' Experience.Brain sciences · 2026Article
- The Decision-Making Process of Antidepressant Use Among Patients with Depression: A Grounded Theory Study.Patient preference and adherence · 2026Article
- Comparative sentiment and thematic analysis of depression-related discourse between healthcare professionals and non-healthcare individuals on Chinese social media: a computational text analysis study.Frontiers in psychology · 2026Article
- Analysis of the Development Trajectory and Influencing Factors of Depression in Patients With Cervical Cancer During Concurrent Chemoradiotherapy.Actas espanolas de psiquiatria · 2025Article
- Functioning of chronically ill patients receiving long-term care in Poland.Frontiers in public health · 2025Article
- Development and Evaluation of an AI Avatar Educational Tool for Depression and Anxiety: A Qualitative Pilot Study.Journal of primary care & community healthArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepression affects approximately 280 million individuals globally and it is a leading cause of disability. Despite effective medication options, 50% of patients prematurely discontinue antidepressants within 6 months. We sought to understand patients' perspectives regarding their needs and expectations related to antidepressants.
objectivesTo identify and describe enablers and barriers that influence adult patients' medication adherence in depression treatment and to explore patients' educational needs on initiating or continuing antidepressant therapy.
methodsQualitative descriptive study was conducted using individual, semi-structured interviews of adult patients with depression who were prescribed an antidepressant within 3 months of study recruitment at an urban primary care clinic in Toronto, Canada. Thirteen participants were interviewed. Interviews were recorded and transcribed verbatim for inductive thematic analysis.
resultsSix themes emerged: safety and effectiveness of antidepressant, understanding of depression and its management, medication administration, healthcare experiences in the treatment of depression, and social influences and relationships. Barriers to adherence included adverse effects of antidepressants, preference for non-pharmacological therapies, uncertainty about therapeutic effects, and social stigma. In contrast, enablers were positive responses from antidepressants, fear of relapse, reminder aids, established routine, and a trusting patient-provider relationship. Participants desired access to reliable, evidence-based, and personalized educational information delivered through verbal, written, and digital formats to support antidepressant adherence.
conclusionTo overcome the identified barriers, educational strategies should involve both patients and their prescribers to identify patient-specific needs and treatment goals, engage in shared decision-making, and maintain consistent follow-up to support antidepressant adherence.
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