ArticleActa ophthalmologica2025
Imprint of preterm birth with very low birth weight on optic disc OCT in adulthood-A two-country birth cohort study.
Article in Acta ophthalmologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Exploring ocular fundus morphology in relation to growth in adolescents born moderate-to-late preterm.Acta ophthalmologica · 2026Article
- Bronchopulmonary dysplasia and extremely preterm birth: time for a broader perspective on long-term outcomes.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- PREVALENCE AND DEGREE OF RETINAL VASCULATURE ALTERATIONS IN ADULTS BORN PRETERM WITH VERY LOW BIRTH WEIGHT: A Birth Cohort Study.Retina (Philadelphia, Pa.) · 2025Article
- Long-Term Ocular Outcomes of Prematurity: Morphological Alterations, Visual Aspects and Implications for Age-Related Ocular Diseases.Journal of clinical medicine · 2025Review
- Imprint of preterm birth with very low birth weight on optic disc OCT in adulthood-A two-country birth cohort study.Acta ophthalmologica · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
purposeTo determine the pattern, degree and prevalence of optic disc optical coherence tomography (OCT) alterations in adults born preterm with very low birth weight (VLBW; birth weight < 1500 g).
methodsOptic disc OCT was assessed in 98 VLBW participants and 139 term-born controls from birth cohorts in Finland and Norway at the mean age of 36 years. The participants had not been treated for retinopathy of prematurity and had no diagnosed brain abnormality. OCT assessment included parameters for optic disc size, neural rim and peripapillary retinal nerve fibre layer thickness (pRNFLT), and for the foveal developmental stage. Background data, visual acuity, refractive error and intraocular pressure were recorded.
resultsIn the VLBW group, optic disc neural rim and pRNFLT were significantly decreased, most frequently in the nasal and inferior sectors. In 40% (95% CI: 33-47) of the VLBW eyes, nerve fibre thickness of at least one optic disc sector was below the fifth percentile of the control group, including 9% (95% CI: 6-14) subgroup falling below the first percentile, that is, clinically below normal limits. VLBW participants with nerve fibre thickness below the fifth percentile did not differ by perinatal data or foveal developmental stage from the other VLBW participants. All participants had normal visual acuity.
conclusionA moderate decrease of the optic disc neural rim and pRNFLT is frequently seen in clinically healthy adults born preterm with VLBW. Awareness of the VLBW-related optic disc nerve fibre shallowness especially in the inferior and nasal sectors is important while evaluating acquired optic disc pathology in adulthood.
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