Evidence map›Paper›PMID 39417277›Full record

ArticleBiology open2024

Distinct roles of COMPASS subunits to Drosophila heart development.

Jun-Yi Zhu, Joyce van de Leemput, Zhe Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Cells · 2025
    Article
  3. International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jun-Yi ZhuCenter for Precision Disease Modeling, Department of Medicine , University of Maryland School of Medicine, 670 West Baltimore Street, Baltimore, MD 21201, USA.ORCID 0000-0002-4517-101X
Joyce van de LeemputCenter for Precision Disease Modeling, Department of Medicine , University of Maryland School of Medicine, 670 West Baltimore Street, Baltimore, MD 21201, USA.
Zhe HanCenter for Precision Disease Modeling, Department of Medicine , University of Maryland School of Medicine, 670 West Baltimore Street, Baltimore, MD 21201, USA.ORCID 0000-0002-5177-7798

Funding

Modeling Nephrotic Syndrome in Drosophila NephrocytesR01DK098410 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI HAN, ZHE · 2014 to 2022
$3.3M
Screen and functional validation of Pediatric Cardiomyopathy genetic variants in DrosophilaR01HD111480 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI ZHE HAN · 2023 to 2026
$2.6M
INCLUDE19-Ancestral roles of histone-modifying genes in heart development and diseaseR01HL134940 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI HAN, ZHE · 2017 to 2020
$2.4M
PDE10A Regulation and Function in Cardiovascular DiseaseR01HL134910 · NHLBI · UNIVERSITY OF ROCHESTER · PI BERK, BRADFORD C, YAN, CHEN · 2017 to 2020
$2.1M
New Drosophila, mouse, and human podocyte models to study HIV-APOL1-G1 associated chronic kidney diseasesR01DK140937 · NIDDK · UNIVERSITY OF VIRGINIA · PI ZHE HAN, PATRICIO E. RAY · 2025 to 2026
$1.6M
NHLBI NIH HHS R01 HL134910NHLBI NIH HHS R01 HL134940NICHD NIH HHS R01 HD111480NIDDK NIH HHS R01 DK098410NIDDK NIH HHS R01 DK140937NIH HHS R01-HL134910University of Maryland School of Medicine
6 · The paper itself

Abstract

The multiprotein complexes known as the complex of proteins associated with Set1 (COMPASS) play a crucial role in the methylation of histone 3 lysine 4 (H3K4). In Drosophila, the COMPASS series complexes comprise core subunits Set1, Trx, and Trr, which share several common subunits such as ash2, Dpy30-L1, Rbbp5, and wds, alongside their unique subunits: Wdr82 for Set1/COMPASS, Mnn1 for Trx/COMPASS-like, and Ptip for Trr/COMPASS-like. Our research has shown that flies deficient in any of these common or unique subunits exhibited high lethality at eclosion (the emergence of adult flies from their pupal cases) and significantly shortened lifespans of the few adults that do emerge. Silencing these common or unique subunits led to severe heart morphological and functional defects. Moreover, specifically silencing the unique subunits of the COMPASS series complexes, Wdr82, Mnn1, and Ptip, in the heart results in decreased levels of H3K4 monomethylation and dimethylation, consistent with effects observed from silencing the core subunits Set1, Trx, and Trr. These findings underscore the critical roles of each subunit of the COMPASS series complexes in regulating histone methylation during heart development and provide valuable insights into their potential involvement in congenital heart diseases, thereby informing ongoing research in heart disease.

Indexed as

Drosophila ProteinsHeartHistonesAnimalsDrosophilaGene Expression Regulation, DevelopmentalMethylationMultiprotein ComplexesProtein SubunitsDrosophila ProteinsHistonesMultiprotein ComplexesProtein SubunitsCommon componentsCOMPASS complexDrosophilaHeart developmentHistone modificationUnique components

Identifiers

PMID39417277
PMCPMC11554255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.