Evidence map›Paper›PMID 39417239›Full record

ArticleHypertension (Dallas, Tex. : 1979)2024

Ultra-Processed Food Consumption and Hypertension Risk in the REGARDS Cohort Study.

Carol R Oladele, Neha Khandpur, Spencer Johnson, Ya Yuan, Vivien Wambugu, Timothy B Plante, Gina S Lovasi, Suzanne Judd

Abstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. New evidence linking lifestyle factors to blood pressure: Focus on 2024 findings.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Aging and sex differences in salt sensitivity of blood pressure.Clinical science (London, England : 1979) · 2025
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carol R OladeleDepartment of Internal Medicine, Equity Research and Innovation Center, Yale School of Medicine, Yale University, New Haven, CT (C.R.O., S. Johnson, V.W.).ORCID 0000-0002-1154-8974
Neha KhandpurDivision of Human Nutrition and Health, Wageningen University, the Netherlands (N.K.).
Spencer JohnsonDepartment of Internal Medicine, Equity Research and Innovation Center, Yale School of Medicine, Yale University, New Haven, CT (C.R.O., S. Johnson, V.W.).
Ya YuanSchool of Public Health, University of Alabama at Birmingham (Y.Y., S. Judd).ORCID 0000-0002-2384-5888
Vivien WambuguDepartment of Internal Medicine, Equity Research and Innovation Center, Yale School of Medicine, Yale University, New Haven, CT (C.R.O., S. Johnson, V.W.).ORCID 0009-0003-9709-1921
Timothy B PlanteLarner College of Medicine, University of Vermont, Burlington (T.B.P.).ORCID 0000-0001-9992-9597
Gina S LovasiDornsife School of Public Health, Urban Health Collaborative, Drexel University, Philadelphia, PA (G.S.L.).ORCID 0000-0003-2613-9599
Suzanne JuddSchool of Public Health, University of Alabama at Birmingham (Y.Y., S. Judd).ORCID 0000-0001-7594-6587

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Food insecurity and hypertension in the Eastern CaribbeanK01HL145347 · NHLBI · YALE UNIVERSITY · PI OLADELE, CAROL RENEE · 2019 to 2023
$797k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K01 HL145347
6 · The paper itself

Abstract

backgroundThis study examined the longitudinal association between ultraprocessed food (UPF) consumption and overall hypertension risk and explored the contribution of UPF to racial disparities in hypertension risk.

methodsWe analyzed data from 5957 participants from the REGARDS cohort study (Reasons for Geographic and Racial Disparities in Stroke) who were free from hypertension during visit 1 (2003-2007), had complete dietary information at visit 1, and completed visit 2 (2013-2016). UPF consumption was measured using the Nova classification system and operationalized as percent calories and grams. The main outcome was incident hypertension. Logistic regression was used for analysis.

resultsThirty-six percent of participants developed hypertension at visit 2. Results showed a positive linear relationship between UPF and hypertension incidence. Aggregate model results showed that participants in the highest UPF consumption quartile had 23% greater odds of incident hypertension compared with the lowest quartile. Multivariable results showed that Black and White participants in the highest consumption quartile had 1.26 (95% CI, 0.92-1.74) and 1.22 (95% CI, 1.01-1.47) greater odds of hypertension compared with those in the lowest quartile, respectively. Analyses using UPF consumption as percent grams showed similar aggregate results; however, race-stratified results differed. Findings were not statistically significant among White participants (odds ratio, 1.09 [95% CI, 0.89-1.33]) but showed higher risk of hypertension among Black participants in the highest versus lowest UPF quartiles (odds ratio, 1.43 [95% CI, 1.01-2.02]).

conclusionsThis study demonstrated that high consumption of UPF is associated with increased hypertension risk. Further research is warranted to better understand differences in the intakes of UPF subgroups that may underpin the racial differences in hypertension incidence observed with different UPF metrics.

Indexed as

Food, ProcessedHypertensionAgedBlack or African AmericanCohort StudiesFast FoodsFemaleFood HandlingHumansIncidenceMaleMiddle AgedRisk FactorsUnited StatesWhitecardiovascular diseaseshypertensionobesityracial disparitiesultra-processed food

Identifiers

PMID39417239
PMCPMC11578763

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.