Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
14 authors.
Tamil Iniyan GunasekaranThe Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, USA.ORCID 0000-0002-8639-5060
Devendra MeenaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK.
Annie J LeeDepartment of Neurology, College of Physicians and Surgeons, Columbia University and the New York Presbyterian Hospital, New York, USA.
Siwei WuDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK.
Logan DumitrescuVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Reisa SperlingDepartment of Neurology, Massachusetts General Hospital, Boston, USA.
Timothy J HohmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-3377-7014
Alzheimer’s Disease Neuroimaging Initiative
A4 Study
Jingxian HuangDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK.
Abbas DehghanDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK.ORCID 0000-0001-6403-016X
Ioanna TzoulakiSystems Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.ORCID 0000-0002-4275-9328
Richard MayeuxThe Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, USA.ORCID 0000-0001-6519-9696
Badri VardarajanThe Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, USA.
Funding
The Health & Aging Brain Study - Health Disparities (HABS-HD)U19AG078109 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI LEIGH A JOHNSON · 2022 to 2026
$181.1M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ADAM M BRICKMAN · 2020 to 2026
$30.1M
Epidemiological and Genetic Investigations of Blood-Based Biomarkers for Alzheimer's Disease in the Multiethnic, Washington Heights, Inwood, Columbia Aging Project (WHICAP)R01AG072474 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, MANLY, JENNIFER JAIE · 2021 to 2025
$13.3M
Gene discovery in multi-ethnic late-onset Alzheimer's disease familiesU01AG066752 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEAL, SUZANNE M, VARDARAJAN, BADRI N · 2020 to 2024
$3.8M
Genetic Association Between Alzheimer's Disease and Cardio-Cerebrovascular Risk FactorsK01AG084849 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Annie J Lee · 2024 to 2026
backgroundGenetic research on Alzheimer's disease (AD) has primarily focused on amyloid-β (Aβ) pathogenesis, with fewer studies exploring tau pathology. Elucidating the genetic basis of tau pathology could identify novel pathways in AD.
methodsWe conducted a genome-wide association study of tau standard uptake value ratios (SUVRs) from
resultsGWAS of tau-SUVR revealed two significant loci: rs78636169 (
conclusionWe identified a novel potential therapeutic target,
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Genome-wide scan of Flortaucipir PET levels finds · full record | OpenQuestion