Evidence map›Paper›PMID 39417100›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Associations of PFASs and Pesticides with Lung Function Changes from Adolescence to Young Adulthood in the ESPINA study.

Kayleigh Kornher, Carlos F Gould, Jomel Meeko Manzano, Katie Baines, Georgia Kayser, Xin Tu, Jose Suarez-Torres, Danilo Martinez, Jose R Suarez-Lopez

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Kayleigh KornherThe Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, 92093, USA.
Carlos F GouldThe Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0002-7736-3905
Jomel Meeko ManzanoThe Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, 92093, USA.
Katie BainesThe Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, 92093, USA.
Georgia KayserThe Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, 92093, USA.
Xin TuThe Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, 92093, USA.
Jose Suarez-TorresFundación Cimas del Ecuador, Quito, Ecuador.
Danilo MartinezFundación Cimas del Ecuador, Quito, Ecuador.
Jose R Suarez-LopezThe Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, 92093, USA.

Funding

Untargeted Analysis ResourceU2CES026533 · NIEHS · UNIVERSITY OF MINNESOTA · PI PETERSON, LISA A · 2015 to 2025
$14.0M
National Exposure Assessment Laboratory at EmoryU2CES026560 · NIEHS · EMORY UNIVERSITY · PI WALLER, LANCE A · 2015 to 2015
$8.3M
The ESPINA Study Follow-up Examination in 2016: Environmental Pollutants and Child/Adolescent DevelopmentR01ES025792 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Raeanne Cristine Moore, Jose Ricardo Suarez · 2016 to 2026
$5.6M
The ESPINA Study 19th Year Follow-Up: A Longitudinal Investigation of Pesticide Exposures in relation to Fertility and Hormonal HealthR01ES030378 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jose Ricardo Suarez · 2020 to 2026
$4.1M
Pesticide exposures, mental health and endocrine disruption among children growing up near pesticide spray sites.K01ES031697 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KAYSER, GEORGIA L. · 2020 to 2023
$594k
Pesticides and Mental Health among Adolescents in Ecuadorian Agricultural CommunitiesR21ES026084 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUAREZ, JOSE RICARDO · 2015 to 2016
$344k
NIEHS NIH HHS K01 ES031697NIEHS NIH HHS R01 ES025792NIEHS NIH HHS R01 ES030378NIEHS NIH HHS R21 ES026084NIEHS NIH HHS U2C ES026533NIEHS NIH HHS U2C ES026560
6 · The paper itself

Abstract

Per- and polyfluoroalkyl substances (PFASs) and pesticides are ubiquitous environmental exposures with increasingly recognized adverse health outcomes; however, their impact on lung function, particularly in combination, remains poorly understood. We included 381 adolescent participants from a prospective cohort study in Ecuador who underwent measurements of serum PFAS (perfluorooctanoic acid [PFOA], perfluorooctanesulfonic acid [PFOS] and perfluorononanoic acid [PFNA]) and urinary herbicides (glyphosate, 2,4D) and fungicides (ethylene thiourea) and had spirometric measurements in either 2016 or 2022. We characterized the association between each PFAS or pesticide and each lung function measure in log-log models estimated via ordinary least squares regression. We used quantile g-computation to assess the association of the mixture of PFAS and pesticides with lung function outcomes. After accounting for multiple hypothesis testing, and in models adjusting for household income, parental education, and exposure to tobacco, we found that, individually, PFOA, glyphosate, and ETU were associated with slight increases in FEV

Indexed as

chemical mixturesendocrine disrupting chemicalspersistent pollutantsspirometryyoung adults

Identifiers

PMID39417100
PMCPMC11483001

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.