Evidence map›Paper›PMID 39416958›Full record

ArticleACS pharmacology & translational science2024

Identification of c[D-Trp-Phe-β-Ala-β-Ala], the First κ-Opioid Receptor-Specific Negative Allosteric Modulator.

Junwei Zhao, Monica Baiula, Elisabetta Cuna, Marco Francescato, Joanna Matalińska, Piotr F J Lipiński, Andrea Bedini, Luca Gentilucci

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junwei ZhaoDept. of Chemistry "G. Ciamician", University of Bologna, Campus Navile - Ue4, via Gobetti 83, Bologna 40129, Italy.
Monica BaiulaDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, Italy.ORCID https://orcid.org/0000-0003-0363-0633
Elisabetta CunaDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, Italy.
Marco FrancescatoDept. of Chemistry "G. Ciamician", University of Bologna, Campus Navile - Ue4, via Gobetti 83, Bologna 40129, Italy.
Joanna MatalińskaDepartment of Neuropeptides, Mossakowski Medical Research Institute, Polish Academy of Sciences, 5 Pawinskiego Street, Warsaw 02-106, Poland.
Piotr F J LipińskiDepartment of Neuropeptides, Mossakowski Medical Research Institute, Polish Academy of Sciences, 5 Pawinskiego Street, Warsaw 02-106, Poland.
Andrea BediniDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, Italy.
Luca GentilucciDept. of Chemistry "G. Ciamician", University of Bologna, Campus Navile - Ue4, via Gobetti 83, Bologna 40129, Italy.ORCID https://orcid.org/0000-0001-9134-3161

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, the fungus secondary metabolite cyclotetrapetide c[Trp-Phe-D-Pro-Phe] (CJ-15,208) and its derivatives deserved some attention for their unusual structure and distinctive in vitro and in vivo activity. These tryptophan-containing noncationic opioid peptides can be truly regarded as versatile picklocks capable of activating all opioid receptors. Intriguingly, minimal modification of the potent κ-opioid receptor (KOR) agonist c[D-Trp-Phe-Gly-β-Ala] (

Identifiers

PMID39416958
PMCPMC11475277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.