Evidence map›Paper›PMID 39416885›Full record

ArticleAnnals of surgical treatment and research2024

A prospective randomized trial comparing the efficacy of temperature-responsive gel with local anesthetics

Mira Yoo, Du-Yeong Hwang, Guan Hong Min, Heeyoung Lee, So Hyun Kang, Sang-Hoon Ahn, Yun-Suhk Suh, Young Suk Park

Abstract read
In one paragraph

Article in Annals of surgical treatment and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mira YooDepartment of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0003-4481-5909
Du-Yeong HwangDepartment of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0003-4494-1382
Guan Hong MinDepartment of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0001-5600-8798
Heeyoung LeeDepartment of Pharmacy, Inje University, Busan, Korea.ORCID https://orcid.org/0000-0001-8099-5025
So Hyun KangDepartment of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0002-8248-9043
Sang-Hoon AhnDepartment of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0001-8827-3625
Yun-Suhk SuhDepartment of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0003-3319-8482
Young Suk ParkDepartment of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0002-6352-9759

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Bariatric surgery is the gold standard for the treatment of morbid obesity, but postoperative pain impedes recovery. Currently available pain-recovery treatments have patient safety concerns. This led to a noninferiority study of Welpass (Genewel Co., Ltd.) Methods: In this single-center prospective randomized clinical trial, patients were assigned in a 1:1 ratio to the treatment group (Welpass) and the control group (On-Q PainBuster), with ketorolac administered as needed after surgery according to the protocol. To assess efficacy, the total amount of ketorolac used up to 72 hours postoperatively was measured. Additionally, ketorolac usage and numerical rating scales (NRS) were recorded at 6, 24, 48, and 72 hours after operation. Results: The total amounts of ketorolac used in the 72 hours postoperatively were 188.0 ± 84.6 mg in the treatment group and 198.7 ± 50.0 mg in the control group. The efficacy of the treatment group was noninferior to that of the control group, since the lower limit (-29.9 mg) of the confidence interval for the difference with the control group was greater than the prespecified noninferiority margin (-35.0 mg). Furthermore, when the NRS was evaluated after bariatric surgery, there was no significant difference in scores between the 2 groups at each time point (P > 0.05). Conclusion: We found no difference in effect on pain between the 2 groups, supporting the use of Welpass in clinical practice for pain management in patients undergoing bariatric surgery.

Indexed as

Bariatric surgeryDrug delivery systemsLocal anestheticsPostoperative painTemperature-responsive gel

Identifiers

PMID39416885
PMCPMC11473320

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.